Artículo
Antipathogenic properties of L actobacillus plantarum on P seudomonas aeruginosa: The potential use of its supernatants in the treatment of infected chronic wounds
Ramos Vernieri, Alberto Nicolás
; Sesto Cabral, María Eugenia
; Noseda, Diego Gabriel
; Bosch, María Alejandra; Yantorno, Osvaldo Miguel
; Valdéz, Juan Carlos
Fecha de publicación:
05/2012
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and The European Tissue Repair Society.
ISSN:
1067-1927
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Pathogenic bacteria delay wound healing through several different mechanisms such as persistent production of inflammatory mediators or maintenance of necrotic neutrophils, which release cytolytic enzymes and free oxygen radicals. One of the most frequent pathogens isolated from infections in chronic wounds is Pseudomonas aeruginosa. This bacterium is extremely refractory to therapy and to host immune attack when it forms biofilms. Therefore, antibiotics and antiseptics are becoming useless in the treatment of these infections. In previous works, we demonstrated thatLactobacillus plantarum has an important antipathogenic capacity on P. aeruginosa. The aim of the present work was to elucidate the mechanism involved in the control of growth of P. aeruginosa on different surfaces by L. plantarum. For this purpose, we investigated the effects of L. plantarum supernatants on pathogenic properties of P. aeruginosa, such as adhesion, viability, virulence factors, biofilm formation, and quorum sensing signal expression. L. plantarum supernatants were able to inhibit pathogenic properties of P. aeruginosa by a quorum quenching mechanism. Theantipathogenic properties mentioned above, together with the immunomodulatory, tissue repair, and angiogenesis properties in the supernatants of L. plantarum, make them an attractive option in infected chronic wound treatment.
Palabras clave:
infected chronic wounds
,
P. aeruginosa
,
L. plantarum supernatant
Archivos asociados
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Identificadores
Colecciones
Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Ramos Vernieri, Alberto Nicolás; Sesto Cabral, María Eugenia; Noseda, Diego Gabriel; Bosch, María Alejandra; Yantorno, Osvaldo Miguel; et al.; Antipathogenic properties of L actobacillus plantarum on P seudomonas aeruginosa: The potential use of its supernatants in the treatment of infected chronic wounds; Wiley Blackwell Publishing, Inc; Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and The European Tissue Repair Society.; 20; 4; 5-2012; 552-562
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