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dc.contributor.author
Magnoni, Leonardo Julián
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dc.contributor.author
Scarlato, Norberto A.
dc.contributor.author
Ojeda, F. Patricio
dc.contributor.author
Wöhler, Otto C.
dc.date.available
2017-09-13T15:39:04Z
dc.date.issued
2013-05
dc.identifier.citation
Magnoni, Leonardo Julián; Scarlato, Norberto A.; Ojeda, F. Patricio; Wöhler, Otto C.; Gluconeogenic pathway does not display metabolic cold adaptation in liver of Antarctic notothenioid fish; Springer; Polar Biology; 36; 5; 5-2013; 661-671
dc.identifier.issn
0722-4060
dc.identifier.uri
http://hdl.handle.net/11336/24151
dc.description.abstract
Antarctic notothenioid fish display specializations related to cope with their chronically cold environment, such as high triacylglycerol (TAG) content in tissues. The metabolic fate of glycerol, a product of TAG mobilization, has not been studied in Antarctic fish. To assess the importance of glycerol as a substrate for gluconeogenesis and to determine whether this pathway is metabolically cold adapted (MCA), key hepatic enzyme activities were measured in Antarctic (Notothenia coriiceps, Gobionotothen gibberifrons, and Chionodraco rastrospinosus) and nonAntarctic (Dissostichus eleginoides, Patagonotothen ramsayi, and Eleginops maclovinus) notothenioid fish. Fructose 1,6-biphosphatase (FBP), phosphoenolpyruvate carboxykinase (PEPCK), and glycerol kinase (GK) activities were similar in both groups at common temperatures (1, 6, 11, or 21 C). In particular, thermal sensitivity for the reactions catalyzed by FBP and PEPCK was analogous between Antarctic and non-Antarctic species, reflected by similar values for Arrhenius energy of activation (Ea) and Q10. Additionally, hepatic glycerol, glucose, and glycogen contents together with plasma glycerol and glucose concentrations were similar for all of the species studied. Our results do not support the concept of MCA in hepatic gluconeogenesis and may indicate that the use of glycerol as a precursor for glucose synthesis by this pathway is of low physiological importance in Antarctic fish.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gluconeogenesis
dc.subject
Glycerol
dc.subject
Tag Mobilization
dc.subject
Antarctic Notothenioid Fish
dc.subject
Metabolic Cold Adaptation
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Gluconeogenic pathway does not display metabolic cold adaptation in liver of Antarctic notothenioid fish
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-06T17:17:02Z
dc.journal.volume
36
dc.journal.number
5
dc.journal.pagination
661-671
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Magnoni, Leonardo Julián. University Of Maine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina
dc.description.fil
Fil: Scarlato, Norberto A.. Instituto Nacional de Investigaciones y Desarrollo Pesquero; Argentina
dc.description.fil
Fil: Ojeda, F. Patricio. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Wöhler, Otto C.. Instituto Nacional de Investigaciones y Desarrollo Pesquero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Polar Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00300-013-1292-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00300-013-1292-x
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