Artículo
Bioinformatic Study of Possible Acute Regulation of Acid Secretion in the Stomach
Lee, Yan Hay Grace; Cerf, Nicole Talia
; Shalaby, Nicholas; Montes, Monica Raquel
; Clarke, Ronald J.
Fecha de publicación:
03/2024
Editorial:
Springer
Revista:
Journal of Membrane Biology
ISSN:
0022-2631
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The gastric H+,K+-ATPase is an integral membrane protein which uses the energy of ATP hydrolysis to pump H+ ions from the parietal cells of the gastric mucosa into the stomach in exchange for K+ ions. It is responsible for the acidic environment of the stomach, which is essential for digestion. Acid secretion is regulated by the recruitment of the H+,K+-ATPase from intracellular stores into the plasma membrane on the ingestion of food. The similar amino acid sequences of the lysine-rich N-termini α-subunits of the H+,K+- and Na+,K+-ATPases, suggests similar acute regulation mechanisms, specifically, an electrostatic switch mechanism involving an interaction of the N-terminal tail with the surface of the surrounding membrane and a modulation of the interaction via regulatory phosphorylation by protein kinases. From a consideration of sequence alignment of the H+,K+-ATPase and an analysis of its coevolution with protein kinase C and kinases of the Src family, the evidence points towards a phosphorylation of tyrosine-7 of the N-terminus by either Lck or Yes in all vertebrates except cartilaginous fish. The results obtained will guide and focus future experimental research.
Palabras clave:
ATPasas
,
regulación enzimática
,
alineamiento de secuencias
,
kinasas
Archivos asociados
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Identificadores
Colecciones
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Lee, Yan Hay Grace; Cerf, Nicole Talia; Shalaby, Nicholas; Montes, Monica Raquel; Clarke, Ronald J.; Bioinformatic Study of Possible Acute Regulation of Acid Secretion in the Stomach; Springer; Journal of Membrane Biology; 257; 1-2; 3-2024; 79-89
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