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dc.contributor.author
Jinde, Seiichiro
dc.contributor.author
Zsiros, Veronika
dc.contributor.author
Jiang, Zhihong
dc.contributor.author
Nakao, Kazuhito
dc.contributor.author
Pickel, James
dc.contributor.author
Kohno, Kenji
dc.contributor.author
Belforte, Juan Emilio
dc.contributor.author
Nakazawa, Kazu
dc.date.available
2024-07-31T13:23:03Z
dc.date.issued
2012-12
dc.identifier.citation
Jinde, Seiichiro; Zsiros, Veronika; Jiang, Zhihong; Nakao, Kazuhito; Pickel, James; et al.; Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation; Cell Press; Neuron; 76; 6; 12-2012; 1189-1200
dc.identifier.issn
0896-6273
dc.identifier.uri
http://hdl.handle.net/11336/241352
dc.description.abstract
Although excitatory mossy cells of the hippocampal hilar region are known to project both to dentate granule cells and to interneurons, it is as yet unclear whether mossy cell activity’s net effect on granule cells is excitatory or inhibitory. To explore their influence on dentate excitability and hippocampal function, we generated a conditional transgenic mouse line, using the Cre/loxP system, in which diphtheria toxin receptor was selectively expressed in mossy cells. One week after injecting toxin into this line, mossy cells throughout the longitudinal axis were degenerated extensively, theta wave power of dentate local field potentials increased during exploration, and deficits occurred in contextual discrimination. By contrast, we detected no epileptiform activity, spontaneous behavioral seizures, or mossy-fiber sprouting 5–6 weeks after mossy cell degeneration. These results indicate that the net effect of mossy cell excitation is to inhibit granule cell activity and enable dentate pattern separation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mossy
dc.subject
Hipocampo
dc.subject
Interneuronas
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-07-29T14:12:05Z
dc.journal.volume
76
dc.journal.number
6
dc.journal.pagination
1189-1200
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Jinde, Seiichiro. National Institutes of Health; Estados Unidos. University of Tokyo; Japón
dc.description.fil
Fil: Zsiros, Veronika. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Jiang, Zhihong. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Nakao, Kazuhito. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Pickel, James. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Kohno, Kenji. Nara Institute of Science and Technology; Japón
dc.description.fil
Fil: Belforte, Juan Emilio. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Nakazawa, Kazu. National Institutes of Health; Estados Unidos
dc.journal.title
Neuron
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530172/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuron.2012.10.036
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