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dc.contributor.author
Mesquita Sousa, Dauana  
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Campos, Nagilla R. C. L.  
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Pereira, Juliana R. F.  
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Gomes, Matheus N.  
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Silva, Carolina R.  
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Cutrim Júnior, Jose A. A.  
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Brito, Danilo R. B.  
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Sampaio, Romildo M.  
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Sargison, Neil D.  
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Lifschitz, Adrian Luis  
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Costa-Junior, Livio M.  
dc.date.available
2024-07-26T15:52:16Z  
dc.date.issued
2023-06  
dc.identifier.citation
Mesquita Sousa, Dauana; Campos, Nagilla R. C. L.; Pereira, Juliana R. F.; Gomes, Matheus N.; Silva, Carolina R.; et al.; Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes; Elsevier Science; Veterinary Parasitology; 318; 6-2023; 1-5  
dc.identifier.issn
0304-4017  
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http://hdl.handle.net/11336/241005  
dc.description.abstract
Citrus fruits are consumed all over the world and their by-products are used for animal feed and essential oils production. This study aimed to evaluate the in vitro and in vivo activity of Citrus aurantium var. Dulcis essential oil (CaEO) combined with ABZ against benzimidazole resistant Haemonchus contortus. In vitro egg hatching assays (EHA) were performed using CaEO and ABZ to estimate the effective concentration to achieve 50% egg death (EC50) values and calculate the test essential oil and drug combinations using a simplex-centroid mixture design. These concentrations were used for a second round of EHAs. Sixteen sheep were randomly allocated into two groups and treated with ABZ and the combination of CaEO and ABZ, and faecal egg count reduction tests were performed. In the first round of EHA, CaEO and ABZ showed EC50 values of 0.57 and 0.0048 mg mL−1, respectively. The H. contortus strain used in the study was shown to be highly benzimidazole resistant, with only 1.5% of parasites having susceptible ß-tubulin SNP genotypes. The ABZ reduced the shedding of nematode eggs by 78%, however, its combination with CaEO reduced faecal egg counts by only 9%. The present study is important to highlight the interferences of natural products in anthelmintic metabolism and consequently in drug efficacy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTHELMINTIC RESISTANCE  
dc.subject
HAEMONCHUS CONTROL  
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PLANT OILS  
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SHEEP DISEASES  
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Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-07-26T13:26:14Z  
dc.journal.volume
318  
dc.journal.pagination
1-5  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Mesquita Sousa, Dauana. Universidade Federal do Maranhao; Brasil  
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Fil: Campos, Nagilla R. C. L.. Universidade Federal do Maranhao; Brasil  
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Fil: Pereira, Juliana R. F.. Universidade Federal do Maranhao; Brasil  
dc.description.fil
Fil: Gomes, Matheus N.. Universidade Federal do Maranhao; Brasil  
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Fil: Silva, Carolina R.. Universidade Federal do Maranhao; Brasil  
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Fil: Cutrim Júnior, Jose A. A.. Federal Institute of Maranhao; Brasil  
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Fil: Brito, Danilo R. B.. Federal Institute of Maranhao; Brasil  
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Fil: Sampaio, Romildo M.. Universidade Federal do Maranhao; Brasil  
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Fil: Sargison, Neil D.. University of Edinburgh; Reino Unido  
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Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
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Fil: Costa-Junior, Livio M.. Universidade Federal do Maranhao; Brasil  
dc.journal.title
Veterinary Parasitology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401723000602  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vetpar.2023.109929