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dc.contributor.author
Rodriguez, Alfredo E.
dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
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dc.contributor.author
Antoniucci, David
dc.contributor.author
Mieres, Juan
dc.contributor.author
Fernandez Pereira, Carlos
dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
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dc.contributor.author
Santaera, Omar
dc.contributor.author
Rubilar, Bibiana
dc.contributor.author
Palacios, Igor F.
dc.contributor.author
Serruys, Patrick W.
dc.date.available
2024-07-26T10:50:46Z
dc.date.issued
2012-09
dc.identifier.citation
Rodriguez, Alfredo E.; Rodriguez Granillo, Gaston Alfredo; Antoniucci, David; Mieres, Juan; Fernandez Pereira, Carlos; et al.; Randomized comparison of cost‐saving and effectiveness of oral rapamycin plus bare‐metal stents with drug‐eluting stents: Three‐year outcome from the randomized oral rapamycin in Argentina (ORAR) III trial; Wiley-liss, div John Wiley & Sons Inc.; Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.; 80; 3; 9-2012; 385-394
dc.identifier.issn
1522-726X
dc.identifier.uri
http://hdl.handle.net/11336/240932
dc.description.abstract
Objectives: The Oral Rapamycin in ARgentina (ORAR) III trial is a randomized study comparing a strategy of oral rapamycin (OR) plus bare-metal stent (BMS) versus a strategy of drug-eluting stents (DES) in patients with de novo coronary lesions. The purpose of this study was to assess the 3 years cost-effectiveness outcome of each strategy. Background: OR after BMS has been associated with reduction of target vessel revascularization (TVR) although its value in long-term efficacy in comparison with DES is unknown. Methods: In three hospitals in Buenos Aires, Argentina, 200 patients were randomized to OR plus BMS (n = 100) or DES (n = 100). Primary objectives were costs and effectiveness. Cost analysis included in-hospital and follow-up costs. Safety was defined as the composite of death, myocardial infarction (MI), and stroke. Efficacy was defined as TVR. Results: Baseline characteristics between groups were similar. The 3-year follow-up rate was 99%. Cardiac mortality was 2% and 5% in OR group and DES group, respectively (P = 0.44). The composite of death, MI and stroke rate was 11% in OR group and 20% in DES group (P = 0.078). TVR rate was 14.5% in OR group and 17.6% in DES group (P = 0.50), respectively. Three year cumulative costs were significantly lower in the OR arm as compared to the DES arm (P = 0.0001) and DES strategy did not result cost-effective according to the non-inferiority test. Conclusions: At 3 years follow-up, there were no differences in effectiveness between the two strategies, and DES strategy was not more cost-effective as compared to OR plus BMS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DRUG ELUTING STENTS
dc.subject
CORONARY
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RESTENOSIS
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Randomized comparison of cost‐saving and effectiveness of oral rapamycin plus bare‐metal stents with drug‐eluting stents: Three‐year outcome from the randomized oral rapamycin in Argentina (ORAR) III trial
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-07-16T11:46:24Z
dc.identifier.eissn
1522-1946
dc.journal.volume
80
dc.journal.number
3
dc.journal.pagination
385-394
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Rodriguez, Alfredo E.. Sanatorio "Otamendi y Miroli S. A."; Argentina. Centro de Estudios en Cardiologia Intervencionista; Argentina
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Fil: Rodriguez Granillo, Gaston Alfredo. Centro de Estudios en Cardiologia Intervencionista; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Antoniucci, David. Careggi Hospital; Italia
dc.description.fil
Fil: Mieres, Juan. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Fernandez Pereira, Carlos. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Sanatorio "Otamendi y Miroli S. A."; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Santaera, Omar. Clínica Ima; Argentina
dc.description.fil
Fil: Rubilar, Bibiana. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Palacios, Igor F.. Colegio Argentino de Cardioangiólogos Intervencionistas; Argentina
dc.description.fil
Fil: Serruys, Patrick W.. Cardialysis; Países Bajos
dc.journal.title
Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/ccd.23352
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ccd.23352
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