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dc.contributor.author
Bozzo, Aida Andrea
dc.contributor.author
Soñez, Carlos Alberto
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Monedero Cobeta, I.
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Rolando, Alicia Nelida
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Romanini, María Cristina
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Cots, Debora Soledad
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Lazarte, M. A.
dc.contributor.author
Gauna, Hector Fernando
dc.contributor.author
Mugnaini, M
dc.date.available
2017-09-12T19:06:31Z
dc.date.issued
2013-11
dc.identifier.citation
Bozzo, Aida Andrea; Soñez, Carlos Alberto; Monedero Cobeta, I.; Rolando, Alicia Nelida; Romanini, María Cristina; et al.; Chronic stress and its effects on adrenal cortex apoptosis in pregnant rats ; Taylor & Francis; Biotechnic And Histochemistry; 89; 4; 11-2013; 296-303
dc.identifier.issn
1052-0295
dc.identifier.uri
http://hdl.handle.net/11336/24079
dc.description.abstract
The model of chronic intermittent stress by immobilization during pregnancy may produce alterations in the mechanisms that maintain adrenal gland homeostasis. In earlier investigations using this model, signifi cant variations in plasma prolactin and corticosterone levels, and adrenal gland weights were observed. We hypothesized that chronic stress causes changes in apoptosis in the adrenal glands of pregnant rats. We identifi ed and quantifi ed apoptotic cells in the adrenal cortex and examined their ultrastructural characteristics using transmission electron microscopy. Adrenal glands of pregnant rats at gestation days 12, 17 and 21 were studied for control and experimental (stressed) rats. Immunolabelling techniques, stereological analysis and image quantifi cation of adrenal gland sections were combined to determine differences in apoptosis in the different cell populations of the adrenal cortex. The apoptotic index of the experimental rats showed a signifi cant reduction at gestation day 17, while at days 12 and 21 there were no differences from controls. Moreover, the apoptotic index of the reticular zones in control and experimental animals showed a signifi cant increase compared to the glomerular and fascicular zones at the three gestation times studied. Chronic stress by immobilization reduced the caspase-dependent apoptotic index at gestation day 17, which may be related to variations in plasma concentrations of estrogens and prolactin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adrenal Cortex
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Apoptosis
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Caspase 3
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Chronic Stress
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Electron Microscopy
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Gestation
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Rats
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Chronic stress and its effects on adrenal cortex apoptosis in pregnant rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-06T19:03:48Z
dc.journal.volume
89
dc.journal.number
4
dc.journal.pagination
296-303
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bozzo, Aida Andrea. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina
dc.description.fil
Fil: Soñez, Carlos Alberto. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina
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Fil: Monedero Cobeta, I.. Universidad Autónoma de Madrid; España
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Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina
dc.description.fil
Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lazarte, M. A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Gauna, Hector Fernando. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
dc.description.fil
Fil: Mugnaini, M. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina
dc.journal.title
Biotechnic And Histochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10520295.2013.846478
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10520295.2013.846478
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