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dc.contributor.author
Brance, María Lorena
dc.contributor.author
Razzini, Agustín
dc.contributor.author
Pons Estel, Bernardo A.
dc.contributor.author
Quagliato, Norberto J.
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Jorfen, Marisa
dc.contributor.author
Berbotto, Guillermo
dc.contributor.author
Brun, Lucas Ricardo Martín
dc.date.available
2024-07-25T10:28:11Z
dc.date.issued
2023-12
dc.identifier.citation
Brance, María Lorena; Razzini, Agustín; Pons Estel, Bernardo A.; Quagliato, Norberto J.; Jorfen, Marisa; et al.; Whole-hand and regional bone mineral density involvement in rheumatoid arthritis; Elsevier; Reumatología Clínica; 19; 10; 12-2023; 555-559
dc.identifier.issn
2173-5743
dc.identifier.uri
http://hdl.handle.net/11336/240797
dc.description.abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetric polyarthritis that can lead to joint deformity and disability and osteoporosis. We aimed to evaluate the whole-hands and regional BMD in RA patients compare to controls. In addition, we evaluated the BMD of the dominant versus non-dominant hands in healthy subjects. We included adult female and male RA patients and control subjects matched by age, sex and BMI. BMD (g/cm2) was measured DXA in lumbar spine (LS), whole-hands and three regions of interest: carpus, metacarpal bones and phalanges. Results: 44 control subjects (49.5±11.8 y) and 60 with RA (52.7±12.7 y) were included. Significant lower BMD in RA patients was found in LS (-8.7%), dominant whole-hand (-9.5%), carpus, metacarpal bones, and phalanges, and non-dominant whole-hand (-8.7%), metacarpal bones, and phalanges compared to controls. A significant positive correlation was found between LS and whole-hand BMD (dominant r=0.63, non-dominant r=0.67). Finally, the whole-hand, metacarpal bones and carpus BMD were significantly higher in the dominant hand compared to non-dominant hand without differences in the ROI phalanges. In conclusion hand BMD was significantly lower in RA patients compared to control subjects and there was a significant correlation with LS BMD. We demonstrated that BMD measurements of the whole-hand, and different ROI (carpus, metacarpal bones and phalanges) by DXA would be an easily reproducible technique to evaluate bone loss. In addition, the whole-hand, metacarpal bones and carpus BMD were significantly higher in the dominant hand compared to non-dominant hand without differences in the phalanges.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
bone mineral density
dc.subject
hands
dc.subject
, rheumatoid arthritis
dc.subject
dominant hand
dc.subject.classification
Reumatología
dc.subject.classification
Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Whole-hand and regional bone mineral density involvement in rheumatoid arthritis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-07-22T13:12:13Z
dc.journal.volume
19
dc.journal.number
10
dc.journal.pagination
555-559
dc.journal.pais
España
dc.description.fil
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Razzini, Agustín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Pons Estel, Bernardo A.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Quagliato, Norberto J.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Jorfen, Marisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Berbotto, Guillermo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.journal.title
Reumatología Clínica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2173574323001089
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.reumae.2023.04.005
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