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dc.contributor.author
Machuca, Laura Marcela
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dc.contributor.author
Murguia, Marcelo Cesar
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dc.contributor.other
Bt Adnan, Suraya Hani
dc.date.available
2024-07-22T17:35:25Z
dc.date.issued
2020
dc.identifier.citation
Machuca, Laura Marcela; Murguia, Marcelo Cesar; Design, Synthesis and Insecticidal Activities of Novel Pirazol Derivatives to Crop Protection; Book Publisher International; 9; 2020; 95-107
dc.identifier.isbn
978-93-90206-37-7
dc.identifier.uri
http://hdl.handle.net/11336/240535
dc.description.abstract
Aryl pyrazoles are compounds that display very interesting biological activities. This chapter reviews recent work of our group in the development of synthetic strategies for the preparation of new examples of these kinds of compounds to crop protection. A series of six N-aryl pyrazoles was synthesized by Michael-type addition reaction. The molecules 5-amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were synthesized from (ethoxymethylene)malononitrile (1) and fluorinated and non-fluorinated aryl hydrazines (2a-f) using ethanol and fluorinated ethanol as solvents at reflux. An excellent regio-selectivity was found when pyrazole de- rivatives were formed as an exclusive product. No other regioisomer or uncyclised hydrazide was observed.Their structures were confirmed by spectroscopy data (1H, 13C, 19F, COSY (correlationspectroscopy), HSQC (heteronuclear single-quantum correlation spectroscopy) and HMBC (heteronuclear multiple-bond correlation spectroscopy); MS (mass-spectrometry). The yields ranged from good to excellent (47% - 93%) under mild reaction conditions. It would indicate a high selectivity in the one-step work procedure. These products (3a-f) and derivatives have a potential academic and industrial use as key intermediates, in special for application in crop protection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Book Publisher International
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
N-ARYL PIRAZOLE
dc.subject
ARYL HIDRAZINE
dc.subject
TUTA ABSOLUTA
dc.subject
5-AMINO-1-ARYL-1H-PIRAZOLE-4-CARNONITRILES
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Design, Synthesis and Insecticidal Activities of Novel Pirazol Derivatives to Crop Protection
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2023-04-11T11:35:54Z
dc.journal.volume
9
dc.journal.pagination
95-107
dc.journal.pais
India
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dc.description.fil
Fil: Machuca, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad de la Cuenca del Plata. Secretaria de Politicas del Conocimiento. Instituto de Investigaciones Científicas (sede Goya); Argentina
dc.description.fil
Fil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bookpi.org/bookstore/product/emerging-trends-in-engineering-research-and-technology-vol-9/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.9734/bpi/etert/v9
dc.conicet.paginas
165
dc.source.titulo
Emerging Trends in Engineering Research and Technology
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