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dc.contributor.author
Marioni, Juliana
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Mugas, María Laura
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Martinez, Florencia
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Romero, Bianca Carolina
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Gomez, Tomás Isaac
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Lingua, Giuliana
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Konigheim, Brenda Salome
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Núñez Montoya, Susana Carolina
dc.date.available
2024-07-22T10:31:43Z
dc.date.issued
2024-02
dc.identifier.citation
Marioni, Juliana; Mugas, María Laura; Martinez, Florencia; Romero, Bianca Carolina; Gomez, Tomás Isaac; et al.; Enhanced photodynamic effect of a natural anthraquinone on Candida tropicalis biofilms using a stepwise irradiation strategy; Elsevier; Phytomedicine Plus; 4; 2; 2-2024; 1-33
dc.identifier.issn
2667-0313
dc.identifier.uri
http://hdl.handle.net/11336/240410
dc.description.abstract
BackgroundAntimicrobial Photodynamic Therapy (aPDT) has demonstrated effectiveness against various Candida biofilms, typical resistant to conventional treatments. Some strategies have shown to enhance the photoactivity of some photosensitizers (PS), such as the use of a multiple irradiation scheme or the combination with drugs that improve the penetration of the PS through the microbial membrane.PurposeHaving demonstrated the photodynamic antibiofilm activity of some natural anthraquinones (AQs), we selected rubiadin 1-methyl ether (R-1ME) that showed a low photo-reduction percentage (%R) on the biofilm mass, with the aim to improve its effect.Study DesignExperimental in vitro photo-stimulation protocols have been developed, which include successive light exposures and the combination of this AQ with a commonly used antifungal such as Amphotericin B (AmB).MethodsThe biofilms reduction was quantified by Crystal Violet staining. Reactive oxygen and nitrosative species were observed as action mechanism, alongside an assessment of antioxidant response through superoxide dismutase enzyme activation and total antioxidant system capacity.ResultsApplying R-1ME to C. tropicalis biofilms with sequential 15-min irradiation sessions at varied incubation intervals (0, 3, 6, 24, 27, and 30 h) yielded a substantial photo-reduction (62.9 %R) on biofilm mass, even halving the bioactive concentration of R-1ME. Moreover, combining R-1ME with AmB under this irradiation pattern produced an even greater impact (82 %R) at concentrations below the Minimal Inhibitory Concentration. Evident redox imbalances in the biofilm were linked to this photosensitized activity.ConclusionsA new strategy was found to improve the activity of a natural PS on fungal biofilms, by combining it with antifungal drugs, under a staged irradiation scheme, which, in turn, required low doses of the PS and the antifungal to achieve this improved photo-reduction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/embargoedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTHAQUINONES
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PHOTODYNAMIC ACTIVITY
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CANDIDA BIOFILMS
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MULTIPLE IRRADIATION STEPS
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OXIDATIVE STRESS
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Enhanced photodynamic effect of a natural anthraquinone on Candida tropicalis biofilms using a stepwise irradiation strategy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-22T11:50:00Z
dc.journal.volume
4
dc.journal.number
2
dc.journal.pagination
1-33
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Marioni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Mugas, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
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Fil: Martinez, Florencia. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
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Fil: Romero, Bianca Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Gomez, Tomás Isaac. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Lingua, Giuliana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
dc.description.fil
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.journal.title
Phytomedicine Plus
dc.rights.embargoDate
2024-08-22
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2667031324000174
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phyplu.2024.100539
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