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dc.contributor.author
Andersen, Øivind
dc.contributor.author
Rubiolo, Juan Andrés
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dc.contributor.author
Pirolli, Davide
dc.contributor.author
Aramburu, Oscar
dc.contributor.author
Pampín, Marina
dc.contributor.author
Righino, Benedetta
dc.contributor.author
Robledo, Diego
dc.contributor.author
Bouza, Carmen
dc.contributor.author
De Rosa, Maria Cristina
dc.contributor.author
Martínez, Paulino
dc.date.available
2024-07-18T14:01:30Z
dc.date.issued
2023-02
dc.identifier.citation
Andersen, Øivind; Rubiolo, Juan Andrés; Pirolli, Davide; Aramburu, Oscar; Pampín, Marina; et al.; Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus); Nature; Scientific Reports; 13; 1; 2-2023; 1-16
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/240262
dc.description.abstract
Non-synonymous variation (NSV) of protein coding genes represents raw material for selection to improve adaptation to the diverse environmental scenarios in wild and livestock populations. Many aquatic species face variations in temperature, salinity and biological factors throughout their distribution range that is reflected by the presence of allelic clines or local adaptation. The turbot (Scophthalmus maximus) is a flatfish of great commercial value with a flourishing aquaculture which has promoted the development of genomic resources. In this study, we developed the first atlas of NSVs in the turbot genome by resequencing 10 individuals from Northeast Atlantic Ocean. More than 50,000 NSVs where detected in the ~ 21,500 coding genes of the turbot genome, and we selected 18 NSVs to be genotyped using a single Mass ARRAY multiplex on 13 wild populations and three turbot farms. We detected signals of divergent selection on several genes related to growth, circadian rhythms, osmoregulation and oxygen binding in the different scenarios evaluated. Furthermore, we explored the impact of NSVs identified on the 3D structure and functional relationship of the correspondent proteins. In summary, our study provides a strategy to identify NSVs in species with consistently annotated and assembled genomes to ascertain their role in adaptation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Evolution
dc.subject
Genetic selection
dc.subject
Productive traits
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-07-18T13:41:58Z
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Andersen, Øivind. Norwegian University of Life Sciences; Noruega
dc.description.fil
Fil: Rubiolo, Juan Andrés. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Laboratorio de Biotecnología Acuática.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Pirolli, Davide. Norwegian University of Life Sciences; Noruega
dc.description.fil
Fil: Aramburu, Oscar. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Pampín, Marina. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Righino, Benedetta. Norwegian University of Life Sciences; Noruega
dc.description.fil
Fil: Robledo, Diego. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Bouza, Carmen. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: De Rosa, Maria Cristina. Norwegian University of Life Sciences; Noruega
dc.description.fil
Fil: Martínez, Paulino. Universidad de Santiago de Compostela; España
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-023-29826-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-023-29826-z
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