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dc.contributor.author
Fermino, Marise L.
dc.contributor.author
Dergan Dylon, Leonardo Sebastian
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Cecílio, Nerry T.
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Santos, Sofia N.
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Toscano, Marta Alicia
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Dias Baruffi, Marcelo
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Roque Barreira, Maria C.
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Bernardes, Emerson S.
dc.date.available
2017-09-12T17:36:42Z
dc.date.issued
2016-08
dc.identifier.citation
Fermino, Marise L.; Dergan Dylon, Leonardo Sebastian; Cecílio, Nerry T.; Santos, Sofia N.; Toscano, Marta Alicia; et al.; Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization; Elsevier; Molecular Immunology; 76; 8-2016; 22-34
dc.identifier.issn
0161-5890
dc.identifier.uri
http://hdl.handle.net/11336/24019
dc.description.abstract
Galectin-3, an endogenous glycan-binding protein, is abundantly expressed at sites of inflammation and immune cell activation. Although this lectin has been implicated in the control of T helper (Th) polarization, the mechanisms underlying this effect are not well understood. Here, we investigated the role of endogenous galectin-3 during the course of experimental Leishmania major infection using galectin-3-deficient (Lgals3-/-) mice in a BALB/c background and the involvement of Notch signaling pathway in this process. Lgals3-/- mice displayed an augmented, although mixed Th1/Th2 responses compared with wild-type (WT) mice. Concomitantly, lymph node and footpad lesion cells from infected Lgals3-/- mice showed enhanced levels of Notch signaling components (Notch-1, Jagged1, Jagged2 and Notch target gene Hes-1). Bone marrow-derived dendritic cells (BMDCs) from uninfected Lgals3-/- mice also displayed increased expression of the Notch ligands Delta-like-4 and Jagged1 and pro-inflammatory cytokines. In addition, activation of Notch signaling in BMDCs upon stimulation with Jagged1 was more pronounced in Lgals3-/- BMDCs compared to WT BMDCs; this condition resulted in increased production of IL-6 by Lgals3-/- BMDCs. Finally, addition of exogenous galectin-3 to Lgals3-/- BMDCs partially reverted the increased sensitivity to Jagged1 stimulation. Our results suggest that endogenous galectin-3 regulates Notch signaling activation in BMDCs and influences polarization of T helper responses, thus increasing susceptibility to L. major infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Galectin-3
dc.subject
Leishmania Major
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Notch Signaling
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T Helper Response
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-31T20:30:14Z
dc.identifier.eissn
1872-9142
dc.journal.volume
76
dc.journal.pagination
22-34
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Fermino, Marise L.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
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Fil: Cecílio, Nerry T.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Santos, Sofia N.. Comissão Nacional de Energia Nuclear. Centro de Radiofarmácia; Brasil
dc.description.fil
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Dias Baruffi, Marcelo. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Roque Barreira, Maria C.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Bernardes, Emerson S.. Comissão Nacional de Energia Nuclear. Centro de Radiofarmácia; Brasil
dc.journal.title
Molecular Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0161589016301079
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1016/j.molimm.2016.06.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/27344022
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