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Artículo

The autocrine/paracrine loop after myocardial stretch: Mineralocorticoid receptor activation

Ennis, Irene LuciaIcon ; Aiello, Ernesto AlejandroIcon ; Cingolani, Horacio EugenioIcon ; Perez, Nestor GustavoIcon
Fecha de publicación: 01/2013
Editorial: Bentham Science Publishers
Revista: Current Cardiology Reviews
ISSN: 1573-403x
e-ISSN: 1875-6557
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs rapidly, constitutes the well-known Frank-Starling mechanism and it is generally attributed to enhanced myofilament responsiveness to Ca2+. The second phase or slow force response (SFR) occurs gradually and is due to an increase in the calcium transient amplitude as a result of a stretch-triggered autocrine/paracrine mechanism. We previously showed that Ca2+ entry through reverse Na+/Ca2+ exchange underlies the SFR, as the final step of an autocrine/paracrine cascade involving release of angiotensin II/endothelin, and a Na+/H+ exchanger (NHE-1) activation-mediated rise in Na+. In the present review we mainly focus on our three latest contributions to the understanding of this signalling pathway triggered by myocardial stretch: 1) The finding that an increased production of reactive oxygen species (ROS) from mitochondrial origin is critical in the activation of the NHE-1 and therefore in the genesis of the SFR; 2) the demonstration of a key role played by the transactivation of the epidermal growth factor receptor; and 3) the involvement of mineralocorticoid receptors (MR) activation in the stretch-triggered cascade leading to the SFR. Among these novel contributions, the critical role played by the MR is perhaps the most important one. This finding may conceivably provide a mechanistic explanation to the recently discovered strikingly beneficial effects of MR antagonism in humans with cardiac hypertrophy and failure.
Palabras clave: Myocardial Stretch , Slow Force Response , Anrep Effect , Mineralocorticoid Receptor , Reactive Oxygen Species , Na+/H+ Exchanger Activation
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/24009
URL: http://www.currentcardiologyreviews.com/articles/114179/the-autocrineparacrine-l
DOI: http://dx.doi.org/10.2174/1573403X113099990034
URL: http://www.eurekaselect.com/114179/article
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Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
Ennis, Irene Lucia; Aiello, Ernesto Alejandro; Cingolani, Horacio Eugenio; Perez, Nestor Gustavo; The autocrine/paracrine loop after myocardial stretch: Mineralocorticoid receptor activation; Bentham Science Publishers; Current Cardiology Reviews; 9; 3; 1-2013; 230-240
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