Artículo
Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape
Li, Qing; Chen, Jieyi; Faux, Pierre; Delgado Burbano, Miguel Eduardo
; Bonfante, Betty; Fuentes Guajardo, Macarena; Mendoza Revilla, Javier; Chacón Duque, J. Camilo; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Jaramillo, Claudia; Arias, William; Barquera, Rodrigo; Everardo Martínez, Paola; Sánchez Quinto, Mirsha; Gómez Valdés, Jorge; Villamil Ramírez, Hugo; Silva de Cerqueira, Caio C.; Hünemeier, Tábita; Ramallo, Virginia
; Wu, Sijie; Du, Siyuan; Giardina, Andrea; Paria, Soumya Subhra; Khokan, Mahfuzur Rahman; Gonzalez-Jose, Rolando
; Schüler-Faccini, Lavinia; Bortolini, Maria Cátira; Acuña Alonzo, Victor; Canizales Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Rojas, Winston; Rothhammer, Francisco; Navarro, Nicolas; Wang, Sijia; Adhikari, Kaustubh; Ruiz-Linares, Andrés
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Fecha de publicación:
12/2023
Editorial:
Nature
Revista:
Communications Biology
ISSN:
2399-3642
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5 × 10−8) at 42 genome regions, nine of which have been previously reported. In follow-up analyses, 26 of the 33 novel regions replicate in East Asians, Europeans, or Africans, and one mouse homologous region influences craniofacial morphology in mice. The novel region in 1q32.3 shows introgression from Neanderthals and we find that the introgressed tract increases nasal height (consistent with the differentiation between Neanderthals and modern humans). Novel regions include candidate genes and genome regulatory elements previously implicated in craniofacial development, and show preferential transcription in cranial neural crest cells. The automated approach used here should simplify the collection of large study samples from across the world, facilitating a cosmopolitan characterization of the genetics of facial features.
Palabras clave:
FACIAL DIVERSITY
,
LATIN AMERICANS
,
MICROEVOLUTION
,
NEANDERTHAL INTROGRESSION
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Li, Qing; Chen, Jieyi; Faux, Pierre; Delgado Burbano, Miguel Eduardo; Bonfante, Betty; et al.; Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape; Nature; Communications Biology; 6; 1; 12-2023; 1-13
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