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dc.contributor.author
Di Palma, María Albana
dc.contributor.author
Alvarez, María Gabriela
dc.contributor.author
Ochoa, Ana Laura
dc.contributor.author
Milanesio, María Elisa
dc.contributor.author
Durantini, Edgardo Néstor
dc.date.available
2017-09-12T16:21:22Z
dc.date.issued
2013-09
dc.identifier.citation
Di Palma, María Albana; Alvarez, María Gabriela; Ochoa, Ana Laura; Milanesio, María Elisa; Durantini, Edgardo Néstor; Optimization of cellular uptake of zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine for maximal photoinactivation of Candida albicans; Elsevier; Fungal Biology; 117; 11-12; 9-2013; 744-751
dc.identifier.issn
1878-6146
dc.identifier.uri
http://hdl.handle.net/11336/23995
dc.description.abstract
Cellular uptake and photodynamic action of zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine (ZnPPc4+) was examined in Candida albicans. In vitro investigations showed that ZnPPc4+ was rapidly bound to C. albicans cells. The binding of phthalocyanine to cells was dependent on ZnPPc4+ concentrations (1–10 μM) and cells densities (106–108 cells mL−1). A high amount of ZnPPc4+ retained in the cells after two washing steps, indicating a strong interaction between the photosensitizer and C. albicans. The uptake was temperature dependent, although the difference between 37 °C and 4 °C was about 10 %. Also, the amount of ZnPPc4+ bound to C. albicans was affected when the cells were incubated for a longer time with azide and 2,4-dinitrophenol (DNP) prior to treatment with ZnPPc4+. Cell survival after irradiation was dependent on the irradiation period, ZnPPc4+ concentration and cells density. Photoinactivation of C. albicans cells was elevated even after two washing steps. The strong dependence of uptake on cell density reveals the strength and avidity of the binding of ZnPPc4+ to C. albicans cells. The accumulation behaviour of ZnPPc4+ suggests that mainly an affinity-mediated binding mechanism can be involved. Therefore, ZnPPc4+ is an interesting phthalocyanine for photodynamic inactivation (PDI) of yeasts in liquid suspensions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Cándida Albicans
dc.subject
Photoinactivation
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Optimization of cellular uptake of zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine for maximal photoinactivation of Candida albicans
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-06T19:02:24Z
dc.journal.volume
117
dc.journal.number
11-12
dc.journal.pagination
744-751
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Di Palma, María Albana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Alvarez, María Gabriela. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ochoa, Ana Laura. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Milanesio, María Elisa. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Fungal Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.funbio.2013.09.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S187861461300130X
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