Artículo
Neuroactive steroids, nociception and neuropathic pain: a flashback to go forward
Fecha de publicación:
16/04/2016
Editorial:
Elsevier Science
Revista:
Steroids
ISSN:
0039-128X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The present review discusses the potential role of neurosteroids / neuroactive steroids in the regulation of nociceptive and neuropathic pain, and recapitulates the current knowledge on the main mechanisms involved in the reduction of pain, especially those occurring at the dorsal horn of the spinal cord, a crucial site for nociceptive processing. We will make special focus on progesterone and its derivative allopregnanolone, which have been shown to exert remarkable actions in order to prevent or reverse the maladaptive changes and pain behaviors that arise after nervous system damage in various experimental neuropathic conditions.
Palabras clave:
Neuropathic Pain
,
Progesterone
,
Allopregnanolone
,
Therapeutic Strategies
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Coronel, Maria Florencia; Labombarda, Maria Florencia; Gonzalez, Susana Laura; Neuroactive steroids, nociception and neuropathic pain: a flashback to go forward; Elsevier Science; Steroids; 110; 16-4-2016; 77-87
Compartir
Altmétricas