Mostrar el registro sencillo del ítem
dc.contributor.author
Toblli, Jorge Eduardo
dc.contributor.author
Cao, Gabriel Fernando
dc.contributor.author
Oliveri, Leda María
dc.contributor.author
Angerosa, Margarita
dc.date.available
2024-07-12T12:54:31Z
dc.date.issued
2012-02
dc.identifier.citation
Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Oliveri, Leda María; Angerosa, Margarita; Evaluation of toxicity and oxidative stress induced by intravenous iron isomaltoside 1000 in a nonclinical model; Ecv-editio Cantor Verlag Medizin Naturwissenschaften; Arzneimittel Forschung Drug Research; 61; 10; 2-2012; 553-565
dc.identifier.issn
0004-4172
dc.identifier.uri
http://hdl.handle.net/11336/239801
dc.description.abstract
The physicochemical characteristics of intravenous iron complexes affect the extent of weakly-bound iron and thus the degree of oxidative stress. The new preparation iron isomaltoside 1000 (IIM) was compared to iron sucrose (IS) and a control group in terms of biochemistry, oxidative stress, inflammatory markers and iron deposition in the liver, heart and kidneys of healthy rats. Renal function was significantly impaired in the IIM group versus both IS and controls. Liver enzymes were also significantly higher in IIM-treated animals versus the other groups, indicative of hepatic injury. Systolic blood pressure was significantly lower following IIM administration compared to IS or control animals. Oxidative stress in the liver, heart and kidneys was greater in the IIM group, as indicated by significantly increased levels of malondialdehyde and antioxidant enzyme activity, accompanied by a significantly lower ratio of reduced to oxidized glutathione. Microscopy demonstrated more extensive positive staining for iron, and a smaller area of ferritin staining, in the liver, heart and kidneys of rats treated with IIM versus IS. Levels of the inflammatory markers TNF-α and IL6 were both significantly higher in the IIM group versus IS in all assessed tissues. These findings indicate that IIM has a less favorable safety profile than IS in healthy rats, adversely affecting iron deposition, oxidative stress and inflammatory responses, with impaired liver and renal function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Ecv-editio Cantor Verlag Medizin Naturwissenschaften
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Intravenous iron
dc.subject
Iron dextran
dc.subject
Iron isomaltoside 1000
dc.subject
Oxidative stress
dc.subject.classification
Otras Medicina Básica
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Evaluation of toxicity and oxidative stress induced by intravenous iron isomaltoside 1000 in a nonclinical model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-06-07T15:49:13Z
dc.journal.volume
61
dc.journal.number
10
dc.journal.pagination
553-565
dc.journal.pais
Alemania
dc.description.fil
Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Oliveri, Leda María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Angerosa, Margarita. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Arzneimittel Forschung Drug Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1300553
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0031-1300553
Archivos asociados