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dc.contributor.author
Veuthey, Tania Vanesa
dc.contributor.author
Burkovski, Andras
dc.date.available
2024-07-12T10:31:32Z
dc.date.issued
2023
dc.identifier.citation
Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases; Third Latinamerican Worm Meeting; Valparaiso; Chile; 2023; 67-68
dc.identifier.uri
http://hdl.handle.net/11336/239727
dc.description.abstract
As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, conventional treatments only attenuate some of the symptoms, but fail to arrest or delaycharacteristic neuronal proteotoxicity that characterizes them.. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. In this context,T the aim of our work was to evaluate the relevance of the microbiota in the development and progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of neurodegenerative disordersND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus the traditional E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva- L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also On the other hand, we obobserved an increase thatin the developmental timing of wild-type worms was increase when animals were grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Universidad de Valparaiso
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROBIOTA
dc.subject
C ELEGANS
dc.subject
neurodegenerativas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-07-10T14:13:10Z
dc.journal.pagination
67-68
dc.journal.pais
Chile
dc.journal.ciudad
Valparaiso
dc.description.fil
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Burkovski, Andras. Universitat Erlangen Nuremberg; Alemania
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://cinv.uv.cl/3rd-la-worm-meeting/
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
Third Latinamerican Worm Meeting
dc.date.evento
2023-03-15
dc.description.ciudadEvento
Valparaiso
dc.description.paisEvento
Chile
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
Latin American Worm Meeting
dc.source.revista
Third Latinamerican Worm Meeting
dc.date.eventoHasta
2023-03-19
dc.type
Congreso
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