Artículo
Effect of thiol compounds on bleomycin-induced DNA and chromosome damage in human cells
Mira, Anabela
; Giménez, Esteban Mariano; Bolzan, Alejandro Daniel
; Bianchi, Martha S.; Lopez Larraza, Daniel Mario
Fecha de publicación:
02/2013
Editorial:
Heldref Publications
Revista:
Archives Of Environmental And Occupational Health
ISSN:
1933-8244
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Non-protein thiols are considered radioprotectors, preventing DNA damage by ionizing radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may prevent DNA damage produced by this antibiotic. However, results obtained with thiols and BLM-combined treatments in living cells are contradictory. The goal of this work was to assess the influence of five non-protein thiols of different electrical charge and chemical composition, on the DNA damage, DNA repair, chromosomal aberrations and cell killing induced by BLM. We found that, at the chromosomal level and cell killing, Glutathione, β-Mercaptoethanol and cysteine showed a protective effect, while ditiothreitol and cysteamine increased them, whereas at the DNA level all thiols potentiated the DNA damage induced by BLM, most probably due to a reactivation of the BLM complex
Palabras clave:
Thiols
,
Bleomycin
,
Chromosomal Aberrations
,
Dna Damage
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Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Mira, Anabela; Giménez, Esteban Mariano; Bolzan, Alejandro Daniel; Bianchi, Martha S.; Lopez Larraza, Daniel Mario; Effect of thiol compounds on bleomycin-induced DNA and chromosome damage in human cells; Heldref Publications; Archives Of Environmental And Occupational Health; 68; 2; 2-2013; 107-116
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