HIV mother-to-child transmission: A complex genetic puzzle tacked by Brazil and Argentina research teams

Human immunodeficiency virus (HIV) mother-to-child transmission is a complex event, depending upon environmental factors and is affected by host genetic factors from mother and child, as well as viral genetic elements. The integration of multiple parameters (CD4 cell count, virus load, HIV subtype, and host genetic markers) could account for the susceptibility to HIV infection, a multifactorial trait. The goal of this manuscript is to analyze the immunogenetic factors associated to HIV mother-to-child transmission, trying to unravel the genetic puzzle of HIV mother-to-child transmission and considering the experience in this topic of two research groups from Brazil and Argentina.

Palabras clave: Mother-To-Child Transmission , Hiv , Host Genome , Immunogenetics Markers , Susceptibility , Protection

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/23960

URL: http://www.sciencedirect.com/science/article/pii/S1567134813000762

DOI: http://dx.doi.org/10.1016/j.meegid.2013.03.005

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Citación

Da Silva, R. Celerino; Bedin, E.; Mangano, Andrea María Mercedes; Aulicino, Paula; Pontillo, A.; et al.; HIV mother-to-child transmission: A complex genetic puzzle tacked by Brazil and Argentina research teams; Elsevier; Infection, Genetics and Evolution; 19; 3-2013; 1-12

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