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dc.contributor.author
Morales, Arturo Leonardo
dc.contributor.author
Figueroa, Marcelo Isidro
dc.contributor.author
Navarro, Jose Pablo
dc.contributor.author
Chaves, Estela Raquel
dc.contributor.author
Ruderman, Anahí
dc.contributor.author
Dipierri, Jose Edgardo
dc.contributor.author
Ramallo, Virginia
dc.date.available
2024-07-10T09:39:22Z
dc.date.issued
2024-04
dc.identifier.citation
Morales, Arturo Leonardo; Figueroa, Marcelo Isidro; Navarro, Jose Pablo; Chaves, Estela Raquel; Ruderman, Anahí; et al.; Volga German surnames and Alzheimer’s disease in Argentina: an epidemiological perspective; Cambridge University Press; Journal Of Biosocial Science; 4-2024; 1-14
dc.identifier.issn
0021-9320
dc.identifier.uri
http://hdl.handle.net/11336/239377
dc.description.abstract
The N141I variant (PSEN1 gene) is associated with familial forms of early-onset Alzheimer’s disease (AD) in descendants of Volga Germans, whose migration to Argentina is well documented. As a proxy for geographic origin, surnames can be a valuable tool in population studies. The 2015 Argentine Electoral Registry provided geographic data for 30,530,194 individuals, including 326,922 with Volga German surnames. Between 2005 and 2017, the Ministry of Health recorded 4,115,216 deaths, of which 17,226 were attributed to AD and related causes. The study used both diachronic and synchronic data to identify patterns of territorial distribution and co-spatiality, using Moran’s I and generalised linear model statistics. The frequency of surnames of Volga German origin accounts for 43.53% of the variation in deaths from AD and three clusters of high non-random frequency were found. Almost 150 years later, people descending from the Volga migration remain highly concentrated and may have a different risk of developing AD. The identification of spatial patterns provides reliable guidance for medical research and highlights the importance of specific health policies for particular populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SURNAME ANALYSIS
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EPIDEMIOLOGY
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VOLGA MIGRATION-DESCENDEND
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ALZHEIMER'S DISEASE
dc.subject.classification
Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Volga German surnames and Alzheimer’s disease in Argentina: an epidemiological perspective
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-06-25T14:56:30Z
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Morales, Arturo Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
dc.description.fil
Fil: Figueroa, Marcelo Isidro. Hospital Materno Infantil Doctor Hector Quintana ; Gobierno de la Provincia de Jujuy; . Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentina
dc.description.fil
Fil: Navarro, Jose Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
dc.description.fil
Fil: Chaves, Estela Raquel. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
dc.description.fil
Fil: Ruderman, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
dc.description.fil
Fil: Dipierri, Jose Edgardo. Hospital Materno Infantil Doctor Hector Quintana ; Gobierno de la Provincia de Jujuy;
dc.description.fil
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
dc.journal.title
Journal Of Biosocial Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S002193202400018X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S002193202400018X/type/journal_article
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