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dc.contributor.author
Londoño Salazar, Jennifer
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Restrepo Acevedo, Andrés
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Torres, John Eduard
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Abonia, Rodrigo
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Svetaz, Laura Andrea
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Zacchino, Susana Alicia Stella
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Le Lagadec, Ronan
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Cuenú Cabezas, Fernando
dc.date.available
2024-07-05T10:58:09Z
dc.date.issued
2024-06
dc.identifier.citation
Londoño Salazar, Jennifer; Restrepo Acevedo, Andrés; Torres, John Eduard; Abonia, Rodrigo; Svetaz, Laura Andrea; et al.; Synthesis and Characterization of New Bases Derived from Nitrophenylpyrazoles, Coordination to Palladium and Antifungal Activity and Catalytic Activity in Mizoroki–Heck Reactions; MDPI; Catalysts; 14; 6; 6-2024; 1-29
dc.identifier.issn
2073-4344
dc.identifier.uri
http://hdl.handle.net/11336/239144
dc.description.abstract
In this study, we report the synthesis of eight Schiff bases (3–10) type N-heterocycle (N-het) using conventional refluxing conditions as well as different eco-friendly techniques such as grinding, thermal fusion, microwave irradiation (MWI) and ultrasound, all of them in the presence of a catalytic amount of acetic acid. These procedures had the additional advantage of being environmentally friendly and high-yield, making these protocols an alternative for Schiff-base syntheses. The obtained Schiff bases were coordinated to palladium, generating new complexes of type [Pd2Cl4(N-het)2]. Complexes [Pd2Cl4(5)2] and [Pd2Cl4(9)2] showed high activity and selectivity for a model Mizoroki– Heck C-C coupling reaction of styrene with iodobenzene and bromobenzaldehydes. All compounds and complexes were evaluated for antifungal activity against clinically important fungi such as Candida albicans and Cryptococcus neoformans. Although the Schiff bases (3–10) showed low antifungal activity against both fungi, some of their palladium complexes such as [Pd2Cl4(3)2], [Pd2Cl4(5)2], [Pd2Cl4(8)2] and [Pd2Cl4(10)2] showed comparatively higher antifungal effects mainly against C. neoformans. The product of the Mizoroki–Heck-type C-C coupling reactions, 4-styrylbenzaldehyde, was isolated and purified to be later used in the synthesis of four new nitrophenylpyrazole derivatives of styrylimine, which also displayed antifungal activity, especially against C. neoformans.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
MIZOROKI-HECK REACTION
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PALLADIUM
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ANTIFUNGAL ACTIVITY
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PYRAZOLE
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Synthesis and Characterization of New Bases Derived from Nitrophenylpyrazoles, Coordination to Palladium and Antifungal Activity and Catalytic Activity in Mizoroki–Heck Reactions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-07-04T11:35:35Z
dc.journal.volume
14
dc.journal.number
6
dc.journal.pagination
1-29
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Londoño Salazar, Jennifer. Universidad del Quindio; Colombia
dc.description.fil
Fil: Restrepo Acevedo, Andrés. Universidad del Quindio; Colombia
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Fil: Torres, John Eduard. Universidad del Quindio; Colombia
dc.description.fil
Fil: Abonia, Rodrigo. Universidad del Valle; Colombia
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Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
dc.description.fil
Fil: Le Lagadec, Ronan. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Cuenú Cabezas, Fernando. Universidad del Quindio; Colombia
dc.journal.title
Catalysts
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4344/14/6/387
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/catal14060387
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