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dc.contributor.author
Morilla, María José
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dc.contributor.author
Ghosal, Kajal
dc.contributor.author
Romero, Eder Lilia
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dc.date.available
2024-07-04T17:25:36Z
dc.date.issued
2024-03
dc.identifier.citation
Morilla, María José; Ghosal, Kajal; Romero, Eder Lilia; Nanomedicines against Chagas disease: A critical review; Beilstein-Institut zur Förderung der Chemischen Wissenschaften; Beilstein Journal of Nanotechnology; 15; 3-2024; 333-349
dc.identifier.uri
http://hdl.handle.net/11336/239117
dc.description.abstract
Chagas disease (CD) is the most important endemic parasitosis in South America and represents a great socioeconomic burden for the chronically ill and their families. The only currently available treatment against CD is based on the oral administration of benznidazole, an agent, developed in 1971, of controversial effectiveness on chronically ill patients and toxic to adults. So far, conventional pharmacological approaches have failed to offer more effective and less toxic alternatives to benznidazole. Nanomedicines reduce toxicity and increase the effectiveness of current oncological therapies. Could nanomedicines improve the treatment of the neglected CD? This question will be addressed in this review, first by critically discussing selected reports on the performance of benznidazole and other molecules formulated as nanomedicines in in vitro and in vivo CD models. Taking into consideration the developmental barriers for nanomedicines and the degree of current technical preclinical efforts, a prospect of developing nanomedicines against CD will be provided. Not surprisingly, we conclude that structurally simpler formulations with minimal production cost, such as oral nanocrystals and/or parenteral nano-immunostimulants, have the highest chances of making it to the market to treat CD. Nonetheless, substantive political and economic decisions, key to facing technological challenges, are still required regarding a realistic use of nanomedicines effective against CD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Beilstein-Institut zur Förderung der Chemischen Wissenschaften
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Nanomedicines
dc.subject
Chagas disease
dc.subject.classification
Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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dc.subject.classification
Biotecnología Industrial
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Nanomedicines against Chagas disease: A critical review
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-06-24T10:06:38Z
dc.identifier.eissn
2190-4286
dc.journal.volume
15
dc.journal.pagination
333-349
dc.journal.pais
Alemania
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dc.journal.ciudad
Frankfurt
dc.description.fil
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Area Química; Argentina
dc.description.fil
Fil: Ghosal, Kajal. Jadavpur University; India
dc.description.fil
Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Area Química; Argentina
dc.journal.title
Beilstein Journal of Nanotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.beilstein-journals.org/bjnano/articles/15/30
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/arxiv/https://doi.org/10.3762/bjnano.15.30
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