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Artículo

Protein conformational diversity correlates with evolutionary rate

Zea, Diego JavierIcon ; Monzón, AlexanderIcon ; Fornasari, Maria SilvinaIcon ; Marino Buslje, Cristina; Parisi, Gustavo DanielIcon
Fecha de publicación: 04/2013
Editorial: Oxford University Press
Revista: Molecular Biology and Evolution
ISSN: 0737-4038
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Native state of proteins is better represented by an ensemble of conformers in equilibrium than by only one structure. The extension of structural differences between conformers characterizes the conformational diversity of the protein. In this study, we found a negative correlation between conformational diversity and protein evolutionary rate. Conformational diversity was expressed as the maximum root mean square deviation (RMSD) between the available conformers in Conformational Diversity of Native State database. Evolutionary rate estimations were calculated using 16 different species compared with human sharing at least 700 orthologous proteins with known conformational diversity extension. The negative correlation found is independent of the protein expression level and comparable in magnitude and sign with the correlation between gene expression level and evolutionary rate. Our findings suggest that the structural constraints underlying protein dynamism, essential for protein function, could modulate protein divergence.
Palabras clave: Evolutionary Rate , Protein Evolution , Conformational Diversity
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/23895
DOI: http://dx.doi.org/10.1093/molbev/mst065
URL: https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/mst065
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Citación
Zea, Diego Javier; Monzón, Alexander; Fornasari, Maria Silvina; Marino Buslje, Cristina; Parisi, Gustavo Daniel; Protein conformational diversity correlates with evolutionary rate; Oxford University Press; Molecular Biology and Evolution; 30; 7; 4-2013; 1500-1503
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