Artículo
Do galectins serve as soluble ligands for immune checkpoint receptors?
Torres, Nicolás
; Baudou, Federico Gastón
; Scheidegger, Marco Adrian
; D'alotto Moreno, Tomas
; Rabinovich, Gabriel Adrián
Fecha de publicación:
04/2024
Editorial:
BioMed Central
Revista:
Journal for ImmunoTherapy of Cancer
ISSN:
2051-1426
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-4
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