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dc.contributor.author
Alfarhani, Bassam
dc.contributor.author
Al Tameemi, Maha
dc.contributor.author
Schenone, Agustina Violeta
dc.contributor.author
Goicoechea, Hector Casimiro
dc.contributor.author
Barbosa Jr., Fernando
dc.contributor.author
Campiglia, Andres D.
dc.date.available
2017-09-07T20:53:05Z
dc.date.issued
2016-06
dc.identifier.citation
Alfarhani, Bassam; Al Tameemi, Maha; Schenone, Agustina Violeta; Goicoechea, Hector Casimiro; Barbosa Jr., Fernando; et al.; Room temperature fluorescence spectroscopy of benzo[a]pyrene metabolites on octadecyl extraction membranes; Elsevier Science; Microchemical Journal; 129; 6-2016; 83-89
dc.identifier.issn
0026-265X
dc.identifier.uri
http://hdl.handle.net/11336/23828
dc.description.abstract
Benzo[a]pyrene (B[a]P) is a prototypic carcinogenic polycyclic aromatic hydrocarbon (PAH), which requires metabolic activation to produce its detrimental effects. Measurement of B[a]P metabolites in human urine could provide a direct way to assess individual differences in susceptibility to PAH-related cancer. This article focuses on the development of screening methodology for the routine analysis of B[a]P metabolites in urine samples. It explores the solid-surface room-temperature fluorescence (RTF) properties of 3-hydroxybenzo[ a]pyrene, benzo[a]pyrene-trans-9,10-dihydrodiol, benzo[a]pyrene-r-7,t-8,c-9-tetrahydrotriol and benzo[a]pyrene-r-7,t-8,c-9,c-10-tetrahydrotetrol previously extracted from urine samples with octadecyl-silica membranes. Relative standard deviations varying from 2.1% (benzo[a]pyrene-r-7,t-8,c-9-tetrahydrotriol) to 8.6% (3-hydroxy-benzo[a]pyrene) are obtained with the aid of fiber optic probe that eliminates the need for manual optimization of signal intensities. Analytical recoveries from human urine samples varied from 87.5 ± 3.1% (3-hydroxy-benzo[a]pyrene) to 99.8± 2.5% (benzo[a]pyrene-r-7,t-8,c-9,c-10-tetrahydrotetrol). The excellent analytical figures of merit and the simplicity of the experimental procedure demonstrate the potential of this approach for screening biomarkers of PAH exposure in numerous urine samples.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Benzo[A]Pyrene
dc.subject
Benzo[A]Pyrene Metabolites
dc.subject
Solid-Phase Extraction
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Room-Temperature Fluorescence
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Urine Analysis
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Asymmetric Least Squares
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Room temperature fluorescence spectroscopy of benzo[a]pyrene metabolites on octadecyl extraction membranes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-04T15:07:41Z
dc.journal.volume
129
dc.journal.pagination
83-89
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Alfarhani, Bassam. University Of Central Florida; Estados Unidos
dc.description.fil
Fil: Al Tameemi, Maha. University Of Central Florida; Estados Unidos
dc.description.fil
Fil: Schenone, Agustina Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
dc.description.fil
Fil: Barbosa Jr., Fernando. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Campiglia, Andres D.. University Of Central Florida; Estados Unidos
dc.journal.title
Microchemical Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0026265X16300911
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.microc.2016.06.010
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