Mostrar el registro sencillo del ítem
dc.contributor.author
Castro Portillo, Enrique
dc.contributor.author
López Izquierdo, Raúl
dc.contributor.author
Sanz García, Ancor
dc.contributor.author
Ortega, Guillermo José
dc.contributor.author
Delgado Benito, Juan F.
dc.contributor.author
Castro Villamor, Miguel A.
dc.contributor.author
Sánchez Soberón, Irene
dc.contributor.author
del Pozo Vegas, Carlos
dc.contributor.author
Martín Rodríguez, Francisco
dc.date.available
2024-06-14T13:16:40Z
dc.date.issued
2022-06
dc.identifier.citation
Castro Portillo, Enrique; López Izquierdo, Raúl; Sanz García, Ancor; Ortega, Guillermo José; Delgado Benito, Juan F.; et al.; Role of prehospital point-of-care N-terminal pro-brain natriuretic peptide in acute life-threatening cardiovascular disease; Elsevier Ireland; International Journal of Cardiology; 364; 6-2022; 126-132
dc.identifier.issn
0167-5273
dc.identifier.uri
http://hdl.handle.net/11336/238149
dc.description.abstract
Introduction: The evidence about the use of natriuretic peptides (NP) to predict mortality in the pre-hospital setting is limited. The main objective of this study is to assess the ability of point-of-care testing (POCT) Nterminal portion of B-type natriuretic peptide (NT-proBNP) to predict 2-day in-hospital mortality of acute cardiovascular diseases (ACVD).Methods: We conducted a multicentric, prospective, observational study in adults with ACVD transferred by ambulance to emergency departments (ED). The primary outcome was 2-day in-hospital mortality. The discrimination capacity of the NT-proBNP was performed through a prediction model trained using a derivation cohort and evaluated by the area under the curve (AUC) of the receiver operating characteristic on a validation cohort.Results: A total of 1006 patients were recruited. The median age was 75 (IQR 63–84) years and 421 (41.85%) were females. The 2-day in-hospital mortality was 5.8% (58 cases). The predictive validity of NT-proBNP, for 2-day mortality reached the following AUC: 0.823 (95%CI: 0.758–0.889, p < 0.001), and the optimal specificity and sensitivity were 73.1 and 82.7. Predictive power of NT-proBNP obtained an AUC 0.549 (95%CI: 0.432–0.865, p 0.215) for acute heart failure, AUC 0.893 (95%CI: 0.617–0.97, p < 0.001) for ischemic heart disease, AUC 0.714 (95%CI: 0.55–0.87, p = 0.0069) for arrhythmia and AUC 0.927 (95%CI: 0.877–0.978, p <0,001) for syncope.Conclusion: POCT NT-proBNP has proven to be a strong predictor of early mortality in ACVD, showing an excellent predictive capacity in cases of syncope. However, this biomarker does not appear to be useful for predicting outcome in patients with acute heart failure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Advanced cardiac life support
dc.subject
Brain natriuretic peptide
dc.subject
Point-of-care testing
dc.subject
Heart diseases
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Role of prehospital point-of-care N-terminal pro-brain natriuretic peptide in acute life-threatening cardiovascular disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-06-14T11:15:01Z
dc.journal.volume
364
dc.journal.pagination
126-132
dc.journal.pais
Irlanda
dc.description.fil
Fil: Castro Portillo, Enrique. Universidad de Valladolid; España
dc.description.fil
Fil: López Izquierdo, Raúl. Universidad de Valladolid; España
dc.description.fil
Fil: Sanz García, Ancor. Hospital de la Princesa; España
dc.description.fil
Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
dc.description.fil
Fil: Delgado Benito, Juan F.. Universidad de Valladolid; España
dc.description.fil
Fil: Castro Villamor, Miguel A.. Universidad de Valladolid; España
dc.description.fil
Fil: Sánchez Soberón, Irene. No especifíca;
dc.description.fil
Fil: del Pozo Vegas, Carlos. Universidad de Valladolid; España
dc.description.fil
Fil: Martín Rodríguez, Francisco. Universidad de Valladolid; España
dc.journal.title
International Journal of Cardiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijcard.2022.06.025
Archivos asociados