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Artículo

Charge regulation phenomenon predicted from the modeling of polypeptide electrophoretic mobilities as a relevant mechanism of amyloid-beta peptide oligomerization

Deiber, Julio AlcidesIcon ; Peirotti, Marta BeatrizIcon ; Piaggio, María Virginia
Fecha de publicación: 03/2016
Editorial: Wiley VCH Verlag
Revista: Electrophoresis
ISSN: 0173-0835
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Electrophoretic mobilities of amyloid-beta (1-40) and (1-42) peptides and their aggregates are modeled to study the amyloidogenic pathway associated with Alzheimer´s Disease. The near molecule pH generated by the intraparticle charge regulation phenomenon during the oligomerization of amyloid-beta (1-40) and (1-42) peptides is evaluated and discussed as a relevantmechanism supporting the “amyloid cascade hypothesis” proposed in the literature. A theoretical framework associated with the oligomerization of amyloidbeta peptides including simple scaling laws and the consideration of electrokinetic and hydrodynamic global properties of oligomers is presented. The central finding is the explanation of the near molecule pH change toward the pI when the oligomerization number increases. These results allow one to rationalize consecutive physical stages that validate the amyloid cascade hypothesis. Concluding remarks involving mainly the effects of pair and intraparticle charge regulation phenomena on the amyloidogenic pathway with some suggestions for future research are provided.
Palabras clave: Amyloid-Beta Peptides , Amyloid Cascade Hypothesis , Charge Regulation Phenomenon , Electrophoretic Mobility , Peptide Oligomerization
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/23808
DOI: http://dx.doi.org/10.1002/elps.201500391
URL: http://onlinelibrary.wiley.com/doi/10.1002/elps.201500391/abstract
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Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Deiber, Julio Alcides; Peirotti, Marta Beatriz; Piaggio, María Virginia; Charge regulation phenomenon predicted from the modeling of polypeptide electrophoretic mobilities as a relevant mechanism of amyloid-beta peptide oligomerization; Wiley VCH Verlag; Electrophoresis; 37; 5-6; 3-2016; 711-718
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