Mostrar el registro sencillo del ítem

dc.contributor.author
Daray, Federico Manuel  
dc.contributor.author
Chiapella, Luciana Carla  
dc.contributor.author
Grendas, Leandro Nicolás  
dc.contributor.author
Alvarez Casiani, Romina  
dc.contributor.author
Olaviaga, Alejandro  
dc.contributor.author
Robetto, Josefina  
dc.contributor.author
Prokopez, Cintia R.  
dc.contributor.author
Carrera Silva, Eugenio Antonio  
dc.contributor.author
Errasti, Andrea Emilse  
dc.contributor.author
Neupane, Sudan  
dc.date.available
2024-06-13T12:30:36Z  
dc.date.issued
2024-05  
dc.identifier.citation
Daray, Federico Manuel; Chiapella, Luciana Carla; Grendas, Leandro Nicolás; Alvarez Casiani, Romina; Olaviaga, Alejandro; et al.; Peripheral blood cellular immunophenotype in suicidal ideation, suicide attempt, and suicide: a systematic review and meta-analysis; Nature Publishing Group; Molecular Psychiatry; 2024; 5-2024; 1-19  
dc.identifier.issn
1359-4184  
dc.identifier.uri
http://hdl.handle.net/11336/238043  
dc.description.abstract
Previous meta-analyses have documented the association of immune-in flammatory pathways with the pathophysiology of Major Depressive Episode (MDE), as reflected by alterations in peripheral blood immune cell counts. However, it remains unclear whether these immunological changes are distinct in individuals experiencing suicidal ideation (SI) or suicidal behavior (SB), beyond the context of an MDE. This systematic review and meta-analysis aimed to examine peripheral immune cell profiles across samples with SI/SB and compare them to healthy controls or patients with MDE. A systematic literature search was conducted in MEDLINE, Embase, and PsycINFO for articles published from inception until June 12, 2023. Two independent reviewers screened the articles for inclusion, extracted data, and assessed the risk of bias using the Newcastle-Ottawa scale. Meta-analyses were performed using a random-effects model to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) for immune cell counts or ratios between groups with and without SI/SB. Heterogeneity across studies was assessed using the restricted maximumlikelihood estimator for tau statistic and I2 -statistic and tested by the Q test. Publication bias was evaluated using the Egger test and funnel plots. Meta-regression analyses were conducted to explore the potential moderating effects of age, gender, current or lifetime SI/SB, and the type of self-harming behavior (SI or SB). The study was registered with PROSPERO (CRD42023433089). The systematic review included 30 studies, with data from 19 studies included in the meta-analyses comprising 139 unique comparisons. Eleven different cell populations or ratios were included, comprising 1973 individuals with SI/SB and 5,537 comparison subjects. White blood cell (WBC) and neutrophil counts were higher in individuals with SI/SB than in controls (WBC:SMD = 0.458; 95% CI = 0.367–0.548; p value≤ 0.001;I2= 0.002% and; Neutrophils: SMD = 0.581; 95% CI= 0.408 –0.753;p < 0.001), indicating an inflammatory process. The neutrophil-to-lymphocyte ratio (NLR) emerged as a potential marker, demonstrating a notable elevation in individuals with SI/SB (SMD = 0.695; 95% CI= 0.054–1.335;p value= 0.033;I2= 94.281%;Q test pvalue ≤ 0.001). The elevated NLR appears to be primarily driven by the increase in neutrophil counts, as no significant differences were found in lymphocyte counts between groups. Comparisons among participants with and without SI/SB and depression revealed similar trends with increased NLR, monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) observed in depressed individuals with SI/SB compared to those without SI/SB. Broad alteration in the peripheral immune cell populations and their ratios were observed in individuals with SI/SB, indicating an immune activation or dysfunction. Notably, these immunological changes were also evident when comparing MDE individuals with and without SI/SB, suggesting that such immunedysfunction associated with suicidality cannot be solely attributed to or explained by depressive symptoms. The NLR, MLR, and PLR ratios, in combination with novel immune cellular and protein biomarkers, open new avenues in understanding the immunological underpinnings of SI/SB. Thesefindings highlight the potential utility of immune markers as part of a multi-modal approach for riskstratification and therapeutic monitoring in SI/SB.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
SUICIDE  
dc.subject
META-ANALYSES  
dc.subject
SYSTEMATIC REVIEW  
dc.subject
IMMUNE  
dc.subject.classification
Psiquiatría  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Peripheral blood cellular immunophenotype in suicidal ideation, suicide attempt, and suicide: a systematic review and meta-analysis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-06-11T11:06:48Z  
dc.journal.volume
2024  
dc.journal.pagination
1-19  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Chiapella, Luciana Carla. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Grendas, Leandro Nicolás. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Alvarez Casiani, Romina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Olaviaga, Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Robetto, Josefina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Prokopez, Cintia R.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Carrera Silva, Eugenio Antonio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Errasti, Andrea Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina  
dc.description.fil
Fil: Neupane, Sudan. University of Oslo; Noruega  
dc.journal.title
Molecular Psychiatry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41380-024-02587-5  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41380-024-02587-5