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dc.contributor.author
Corradi, Jeremias
dc.contributor.author
Bouzat Cecilia
dc.contributor.other
Sica, Mauricio Pablo
dc.date.available
2024-06-11T11:03:43Z
dc.date.issued
2016
dc.identifier.citation
Structural and functional characterization of human heteromeric 5-HT3 receptors; III Latin American Federation of Biophysical Societies; IX IberoAmerican Congress of Biophysics; XLV Reunion Anual Sociedad Argentina de Biofísica 2016; Tucumán; Argentina; 2016; 240-240
dc.identifier.uri
http://hdl.handle.net/11336/237739
dc.description.abstract
5-HT3 receptors are members of the Cys-loop receptor family that mediate fast excitatory transmission in central and peripheral nervous system. Genes for five different subunits (A-E) have been identified in humans, and most of the subunits have multiple isoforms. The A subunit is capable of forming functional homomeric (5-HT3A), or heteromeric receptors with the B subunit (5-HT3AB). Here we combine singlechannel and macroscopic current recordings to determine if other 5- HT3 subunits, Br1, Br2, C, D and E (B-E), can combine with the A subunit to form heteromeric receptors. After co-expression of the A subunit with each of the tested subunits, single-channel events with different conductance and kinetic properties with respect to those of 5-HT3A receptors were detected, except for the Br2 subunit. These results indicate that B-E subunits can assemble into functional heteromeric receptors with the A subunit. From the corresponding recordings, the analysis of the single-channel amplitude of the opening events suggests a possible stoichiometry for each heteromeric receptor, since each subunit (B-E).
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Sociedad Argentina de Biofísica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SEROTONIN
dc.subject
RECEPTORS
dc.subject
PATCH-CLAMP
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Structural and functional characterization of human heteromeric 5-HT3 receptors
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-05-29T15:43:35Z
dc.journal.pagination
240-240
dc.journal.pais
Argentina
dc.journal.ciudad
San Carlos de BarilocheS
dc.description.fil
Fil: Corradi, Jeremias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
dc.description.fil
Fil: Bouzat Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://biofisica.org.ar/reuniones-cientificas/reunionsab-previas/
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
III Latin American Federation of Biophysical Societies; IX IberoAmerican Congress of Biophysics; XLV Reunion Anual Sociedad Argentina de Biofísica 2016
dc.date.evento
2016-11-23
dc.description.ciudadEvento
Tucumán
dc.description.paisEvento
Argentina
dc.type.publicacion
Book
dc.description.institucionOrganizadora
Sociedad Argentina de Biofísica
dc.source.libro
III Latin American Federation of Biophysical Societies; IX IberoAmerican Congress of Biophysics; XLV Reunion Anual Sociedad Argentina de Biofísica 2016
dc.date.eventoHasta
2016-11-25
dc.type
Congreso
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