Mostrar el registro sencillo del ítem

dc.contributor.author
Menzel, Stephan  
dc.contributor.author
Rissiek, Björn  
dc.contributor.author
Haag, Friedrich  
dc.contributor.author
Goldbaum, Fernando Alberto  
dc.contributor.author
Koch Nolte, Friedrich  
dc.date.available
2017-09-07T14:07:54Z  
dc.date.issued
2013-08  
dc.identifier.citation
Menzel, Stephan; Rissiek, Björn; Haag, Friedrich; Goldbaum, Fernando Alberto; Koch Nolte, Friedrich; The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs; Wiley Blackwell Publishing, Inc; Febs Journal; 280; 15; 8-2013; 3543-3550  
dc.identifier.issn
1742-464X  
dc.identifier.uri
http://hdl.handle.net/11336/23753  
dc.description.abstract
In 1901, the first Nobel Prize in Physiology or Medicine was awarded to Emil von Behring for his ground-breaking discovery of serum therapy: serum from horses vaccinated with toxin-containing culture medium of Corynebacterium diphtheriae contained life-saving 'antitoxins'. The molecular nature of the ADP-ribosylating toxin and the neutralizing antibodies were unraveled only 50 years later. Today, von Behring's antibody therapy is being refined with a new generation of recombinant antibodies and antibody fragments. Nanobodies, which are single-domain antibodies derived from the peculiar heavy-chain antibodies of llamas and other camelids, are emerging as a promising new class of highly specific enzyme inhibitors. In this review, we illustrate the potential of nanobodies as tools to block extracellular and intracellular ADP-ribosyltransferases (ARTs), using the toxin-related membrane-bound mammalian ecto-enzyme ARTC2 and the actin-ADP-ribosylating Salmonella virulence plasmid factor B toxin of Salmonella enterica as examples.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Nanobodies  
dc.subject
Adp-Rybosil Tranferases  
dc.subject
Salmonella  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-08-29T15:39:32Z  
dc.identifier.eissn
1742-4658  
dc.journal.volume
280  
dc.journal.number
15  
dc.journal.pagination
3543-3550  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Oxford  
dc.description.fil
Fil: Menzel, Stephan. University Medical Center Hamburg-Eppendorf; Alemania  
dc.description.fil
Fil: Rissiek, Björn. University Medical Center Hamburg-Eppendorf; Alemania  
dc.description.fil
Fil: Haag, Friedrich. University Medical Center Hamburg-Eppendorf; Alemania  
dc.description.fil
Fil: Goldbaum, Fernando Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Koch Nolte, Friedrich. University Medical Center Hamburg-Eppendorf; Alemania  
dc.journal.title
Febs Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/febs.12313  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/febs.12313