Artículo
The vehicle of administration, feed or water, and prandial state influence the oral bioavailability of amoxicillin in piglets
Decundo, Julieta María
; Dieguez, Susana Nelly; Martínez, Guadalupe
; Amanto, Andres Fabian; Pérez, Denisa Soledad
; Soraci, Alejandro Luis
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
04/2024
Editorial:
Springer Science and Business Media B.V.
Revista:
Veterinary Research Communications
ISSN:
1573-7446
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Feed and water components may interact with drugs and affect their dissolution and bioavailability. The impact of the vehicle of administration (feed and water) and the prandial condition of weaner piglets on amoxicillin´s oral bioavail-ability was evaluated. First, amoxicillin’s in vitro dissolution and stability in purified, soft, and hard water, as well as release kinetics from feed in simulated gastric and intestinal media were assessed. Then, pharmacokinetic parameters and bioavailability were determined in fasted and fed pigs using soft water, hard water, or feed as vehicles of administration following a balanced incomplete block design. Amoxicillin showed similar dissolution profiles in soft and hard water, distinct from the dissolution profile obtained with purified water. Complete dissolution was only achieved in purified water, and merely reached 50% in soft or hard water. Once dissolved, antibiotic concentrations decreased by around 20% after 24 h in all solutions. Korsmeyer-Peppas model best described amoxicillin release from feed in simulated gastric and intestinal media. Feed considerably reduced antibiotic dissolution in both simulated media. In vivo, amoxicillin exhibited significantly higher bioavailability when delivered via water to fasted than to fed animals, while in-feed administration yielded the lowest values. All treatments showed a similar rate of drug absorption. In conclusion, we demonstrated that water and feed components, as well as feed present in gastrointestinal tract of piglets decrease amoxicillin´s oral bioavail-ability. Therefore, the use of oral amoxicillin as a broad-spectrum antibiotic to treat systemic infections in pigs should be thoroughly revised.
Palabras clave:
AMOXICILLIN
,
FEED
,
WATER HARDNESS
,
BIOAVAILABILITY
,
PRANDIAL STATE
,
PIGLETS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Decundo, Julieta María; Dieguez, Susana Nelly; Martínez, Guadalupe; Amanto, Andres Fabian; Pérez, Denisa Soledad; et al.; The vehicle of administration, feed or water, and prandial state influence the oral bioavailability of amoxicillin in piglets; Springer Science and Business Media B.V.; Veterinary Research Communications; 2024; 4-2024; 1-10
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