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dc.contributor.author
Parisi, Mónica Graciela
dc.contributor.author
Ozón, Brenda
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dc.contributor.author
Vera González, Sofía Macarena
dc.contributor.author
García Pardo, Javier
dc.contributor.author
Obregon, Walter David
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dc.date.available
2024-06-06T12:55:40Z
dc.date.issued
2024-04
dc.identifier.citation
Parisi, Mónica Graciela; Ozón, Brenda; Vera González, Sofía Macarena; García Pardo, Javier; Obregon, Walter David; Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 16; 5; 4-2024; 1-15
dc.identifier.issn
1999-4923
dc.identifier.uri
http://hdl.handle.net/11336/237335
dc.description.abstract
Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant’s defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broadspectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
PLANT PROTEASE INHIBITORS
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ANTIBACTERIAL COMPOUNDS
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ANTIMICROBIAL ACTIVITY
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ANTIMICROBIAL PEPTIDES
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ANTIBIOTIC RESISTANCE
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ANTIFUNGAL AGENTS
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CYSTEINE-RICH PEPTIDES
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-27T11:07:52Z
dc.journal.volume
16
dc.journal.number
5
dc.journal.pagination
1-15
dc.journal.pais
Suiza
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dc.description.fil
Fil: Parisi, Mónica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina
dc.description.fil
Fil: Ozón, Brenda. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
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Fil: Vera González, Sofía Macarena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
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Fil: García Pardo, Javier. Universitat Autònoma de Barcelona; España
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Fil: Obregon, Walter David. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/pharmaceutics16050582
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/16/5/582
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