Artículo
Inference of the force pattern acting on a semiflexible filament from shape analysis
Wenger, Julieta; Brigante, Azul María; Fernández Casafuz, Agustina Belén
; Bruno, Luciana
; Monastra, Alejandro Gabriel
Fecha de publicación:
12/2023
Editorial:
American Physical Society
Revista:
Physical Review E: Statistical, Nonlinear and Soft Matter Physics
ISSN:
1539-3755
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The study of the active forces acting on semiflexible filaments networks such as the cytoskeleton requires noninvasive tools able to explore the deformation of single filaments in their natural environment. We propose here a practical method based on the solution of the hydrodynamic beam equation in the presence of transverse forces. We found that the derivative of the local curvature presents discontinuities that match the location of the applied forces, in contrast to the smooth curvature function obtained for the case of compressing longitudinal forces. These patterns can be easily appreciated in a kymograph of the curvature, which also reflects the temporal behavior of the forces. We assessed the method performance with numerical simulations describing the deformation of single microtubules provoked by the action of intracellular active forces.
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Articulos (IC)
Articulos de INSTITUTO DE CALCULO
Articulos de INSTITUTO DE CALCULO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Wenger, Julieta; Brigante, Azul María; Fernández Casafuz, Agustina Belén; Bruno, Luciana; Monastra, Alejandro Gabriel; Inference of the force pattern acting on a semiflexible filament from shape analysis; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 108; 6; 12-2023; 1-10
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