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dc.contributor.author
Kirse, Thomas M.
dc.contributor.author
Maisuls, Iván
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Denofrio, Maria Paula
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dc.contributor.author
Hepp, Alexander
dc.contributor.author
Cabrerizo, Franco Martín
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dc.contributor.author
Strassert, Cristian A.
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dc.date.available
2024-06-06T12:01:56Z
dc.date.issued
2024-04
dc.identifier.citation
Kirse, Thomas M.; Maisuls, Iván ; Denofrio, Maria Paula; Hepp, Alexander; Cabrerizo, Franco Martín; et al.; Functional Pt(II) and Re(I) Complexes with CO- and β-Carboline-Based Coligands: From Time-Resolved Photoluminescence Spectroscopy and Evaluation of 1O2 Photosensitization Efficiency toward in vitro (Photo)cytotoxicity; American Chemical Society; Organometallics; 2024; 4-2024; 1-64
dc.identifier.issn
1520-6041
dc.identifier.uri
http://hdl.handle.net/11336/237283
dc.description.abstract
In this study, the synthesis, photophysical characterization, and (photo)biological assessment of functional rhenium(I)- and platinum(II)-based complexes are presented. These compounds feature anionic 1,2,4-triazolylpyridine-based chromophores and neutral βC-based monodentate coligands, specifically 9H-pyrido[3,4-b]indole (nHo) or 9-methyl-9H-pyrido[3,4-b]indole (MenHo), which have been chosen to promote their biological activity. The impact of transition metal cations, coordination geometries, substitution patterns of the luminophore and coligands on the properties of these complexes was thoroughly assessed, encompassing photoluminescence and singlet dioxygen (1O2) quantum yields, excited state lifetimes, and (non)radiative rate constants, across various temperatures and phases. Superior photophysical characteristics were attained by the Pt(II)-based complexes, while effective capabilities as photosensitizers of 1O2 were observed for all coordination compounds. Incorporation of these complexes into a polymeric matrix (PMMA) significantly enhanced their luminescence efficiencies by preventing diffusional quenching arising from triplet dioxygen (3O2). Furthermore, a comprehensive (photo)cytotoxicity study on human telomerase reverse transcriptase (hTERT)-immortalized cells was conducted to assess the potential applications of these complexes in photodynamic therapy. In summary, a versatile platform for designing photofunctional materials with photosensitizing properties is offered by this coordination chemical approach. Precise control of photophysical and (photo)biological attributes is achievable through the careful selection of metal centers, substitution patterns, and ancillary ligands.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Excited states
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Group 10 complexes
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Organic compounds
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Photoluminescence
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Quantum yield
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Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Functional Pt(II) and Re(I) Complexes with CO- and β-Carboline-Based Coligands: From Time-Resolved Photoluminescence Spectroscopy and Evaluation of 1O2 Photosensitization Efficiency toward in vitro (Photo)cytotoxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-27T10:59:25Z
dc.journal.volume
2024
dc.journal.pagination
1-64
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Kirse, Thomas M.. Universität Münster; Alemania
dc.description.fil
Fil: Maisuls, Iván. Universität Münster; Alemania
dc.description.fil
Fil: Denofrio, Maria Paula. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina
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Fil: Hepp, Alexander. Universität Münster; Alemania
dc.description.fil
Fil: Cabrerizo, Franco Martín. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina
dc.description.fil
Fil: Strassert, Cristian A.. Universität Münster; Alemania
dc.journal.title
Organometallics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.organomet.3c00539
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.organomet.3c00539
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/suppl/10.1021/acs.organomet.3c00539/suppl_file/om3c00539_si_001.pdf
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