Artículo
Fosfomycin mitigated apoptosis while increased mucin secretion in swine intestinal explants challenged by Lawsonia intracellularis
Pérez, Denisa Soledad
; Fodor, Cristina; Decundo, Julieta María
; Martínez, Guadalupe
; Mozo, Joaquín; Eguia, Valeria Raquel; Dieguez, Susana Nelly; Soraci, Alejandro Luis
; Cobo, Eduardo R.
Fecha de publicación:
03/2024
Editorial:
Elsevier
Revista:
Pharmacological Research - Reports
ISSN:
2950-2004
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Lesions induced by the obligate intracellular bacterium Lawsonia intracellularis, the etiological agent of porcine proliferative enteropathy, are characterized by crypt hyperplasia in the intestinal epithelium with minimal inflammatory infiltration. An increased population of immature enterocytes at the expense of reduced goblet cells suggests that dysregulated apoptosis may be crucial in the pathogenesis of L. intracellularis. Fosfomycin, a widely employed antibiotic in swine production, has also exhibited non-microbicidal effects, encompassing immunomodulation, augmentation of phagocytosis, and the promotion of cell survival. In this study, we assessed the immunomodulatory impact of fosfomycin on intestinal epithelial homeostasis using porcine intestinal explants challenged with L. intracellularis. Our findings reveal that L. intracellularis elicited significant nuclear alterations, increased apoptotic indices, and prompted extensive mucin secretion in the intestinal explants. When fosfomycin was added to L. intracellularis- challenged intestinal explants, it mitigated the degree of apoptosis but also induced an inflammatory response. Consequently, treatment with fosfomycin in the context of L. intracellularis challenge appears to initiate an early mucosal response, maintaining cell viability, preserving the mucin barrier, and fostering inflammatory recruitment.
Palabras clave:
FOSFOMYCIN
,
SWINE
,
LAWSONIA INTRACELLULARIS
,
INTESTINAL
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Pérez, Denisa Soledad; Fodor, Cristina; Decundo, Julieta María; Martínez, Guadalupe; Mozo, Joaquín; et al.; Fosfomycin mitigated apoptosis while increased mucin secretion in swine intestinal explants challenged by Lawsonia intracellularis; Elsevier; Pharmacological Research - Reports; 2; 3-2024; 1-8
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