Limonene exerts antiproliferative effects and increases nitric oxide levels on a lymphoma cell line by dual mechanism of the ERK pathway: Relationship with oxidative stress

D-limonene is a common monoterpene found in nature. Previously, it has been demonstratedthat it has antiproliferative effects on a lymphoma cell line by increasing the nitric oxide (NO)level. In the present work this mechanism is analyzed by evaluating the participation of MAP38and ERK pathways. Limonene increased the NO levels by inducing cell apoptosis by two mechanisms:through the production of H2O2 and ERK pathway activation at low concentrations, andthrough the inhibition of farnesylation of proteins and O−2 production at high concentrations.Both mechanisms were related to the increase in total nitrites, and the production of oxidativestress intermediates was involved.

Palabras clave: Limonene

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/236837

URL: https://www.tandfonline.com/doi/full/10.3109/07357900903179583

DOI: http://dx.doi.org/10.3109/07357900903179583

Colecciones

Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Manuele, Maria Gabriela; Barreiro Arcos, María Laura; Davicino, Roberto Carlos; Ferraro, Graciela Ester; Cremaschi, Graciela Alicia; et al.; Limonene exerts antiproliferative effects and increases nitric oxide levels on a lymphoma cell line by dual mechanism of the ERK pathway: Relationship with oxidative stress; Taylor & Francis; Cancer Investigation; 28; 2; 2-2010; 135-145

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