Artículo
Viral diversity of Junín virus field strains
Goñi, Sandra Elizabeth
; Stephan, Betina Inés
; Iserte, Javier Alonso
; Contigiani de Minio, Marta Silvia; Lozano, Mario Enrique
; Antonio Tenorio
Fecha de publicación:
09/2011
Editorial:
Elsevier Science
Revista:
Virus Research
ISSN:
0168-1702
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The Argentine Hemorrhagic Fever, an endemic disease present in a much of Argentina, is caused by the Junín virus (JUNV). Currently, there are sequences available from several strains of this virus, like those belonging to the vaccine lineage (XJ13, XJ#44 and Candid#1), as well as MC2 (rodent isolate) and IV4454 (human isolate). In this article, we report sequence information on two fragments of genomic segment S of viral isolates from the endemic area. A Nested-RT-PCR was used to amplify discrete genomic regions of 13 isolates of rodent and human origin. The bioinformatics studies revealed a great homogeneity of sequences among the JUNV isolates. The phylogenetic classification showed greater evolutionary distance between the old world arenaviruses (Lassa and LCM virus) than between the new world arenaviruses (JUNV and Machupo virus).
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Citación
Goñi, Sandra Elizabeth; Stephan, Betina Inés; Iserte, Javier Alonso; Contigiani de Minio, Marta Silvia; Lozano, Mario Enrique; et al.; Viral diversity of Junín virus field strains; Elsevier Science; Virus Research; 160; 1-2; 9-2011; 150-158
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