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dc.contributor.author
Ciampi de Andrade, Daniel
dc.contributor.author
Mylius, Veit
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Perez Lloret, Santiago
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Cury, Rubens G.
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Bannister, Kirsty
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Moisset, Xavier
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Taricani Kubota, Gabriel
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Finnerup, Nanna B.
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Bouhassira, Didier
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Chaudhuri, Kallol Ray
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Graven Nielsen, Thomas
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Treede, Rolf Detlef
dc.date.available
2024-05-30T10:51:15Z
dc.date.issued
2023-11
dc.identifier.citation
Ciampi de Andrade, Daniel; Mylius, Veit; Perez Lloret, Santiago; Cury, Rubens G.; Bannister, Kirsty; et al.; Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them; Lippincott Williams; Pain; 164; 11; 11-2023; 2425-2434
dc.identifier.issn
1872-6623
dc.identifier.uri
http://hdl.handle.net/11336/236509
dc.description.abstract
Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD both in prodromal phases and during the subsequent stages of the disease, negatively affecting patient's quality of life and function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targeting motor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD-related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or pain subtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different types of PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic. This is also in line with the International Classification of Disease-11 , which acknowledges the possibility of chronic secondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinion article, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced when classifying it as a stepping stone to discuss an integrative view of the current classification approaches and how clinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeutic efforts are presented, as well as a potential framework to address them in a patient-oriented manner.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
parkinson's disease
dc.subject
pain
dc.subject
diagnosis
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treatment
dc.subject.classification
Neurología Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-22T10:45:56Z
dc.journal.volume
164
dc.journal.number
11
dc.journal.pagination
2425-2434
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Ciampi de Andrade, Daniel. Université Paul Sabatier; Francia
dc.description.fil
Fil: Mylius, Veit. Philipps University; Alemania
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Fil: Perez Lloret, Santiago. Laboratorio de Investigacion En Ciencias de Datos ; Vicerrectorado de Investigacion E Innovacion Academica ; Pontificia Universidad Catolica Argentina "santa Maria de Los Bs. As."; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cury, Rubens G.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Bannister, Kirsty. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Moisset, Xavier. Université Clermont Auvergne; Francia
dc.description.fil
Fil: Taricani Kubota, Gabriel. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Finnerup, Nanna B.. University Aarhus; Dinamarca
dc.description.fil
Fil: Bouhassira, Didier. Inserm; Francia
dc.description.fil
Fil: Chaudhuri, Kallol Ray. University College London; Estados Unidos
dc.description.fil
Fil: Graven Nielsen, Thomas. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Treede, Rolf Detlef. Universidade de Sao Paulo; Brasil
dc.journal.title
Pain
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/j.pain.0000000000002968
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