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dc.contributor.author
Portas, Mercedes
dc.contributor.author
Dubner, Diana
dc.contributor.author
Taja, María Emilia
dc.contributor.author
Gallegos, Cristina Eugenia
dc.contributor.author
Michelin, Severino
dc.contributor.other
Lopes Pereima, Mauricio José
dc.date.available
2024-05-27T13:14:26Z
dc.date.issued
2013
dc.identifier.citation
Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome); VIII Congresso Brasileiro de Queimaduras; Florianopolis; Brasil; 2012; 6-10
dc.identifier.uri
http://hdl.handle.net/11336/236071
dc.description.abstract
Late effects of radiation are generally irreversible and can have devastating effects on quality of life of people exposed either accidentally or during therapeutic radiation treatments. Although many etiologies have been suggested regarding these late toxicities, inflammatory parameters involved during the late phase are less known. Objective: The aim of this study was to analyze the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures. Methods: The follow up of twenty five patients, out of 160 referred to Burn Hospital from 1997, that showed late cutaneous reactions graded according to the RTOG / EORTC system is reported here.The expression of adhesion molecules ICAM1 and β1-integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes were evaluated by flow cytometry and the level of C-reactive protein, a well-studied inflammatory marker was quantified by an immunoturbidimetric assay. Results: The analysis of adhesion molecules expression revealed a higher expression of β1 Integrin on lymphocytes of Grade IV patients compared to non-exposed controls. It was also noted a decrease in its expression values in the follow up of patients with good response to therapeutic treatment. This was paralleled by a tendency to a decrease in the T(CD4+) / T(CD8+) ratio of G4 patients with bad evolution compared to G4 patients with good evolution.The level of C Reactive Protein (CRP) showed higher values in patients in acute phase and patients with late toxicity but in exacerbation crisis. Conclusions: The parameters analyzed, which require confirmation in a larger study, in combination with other inflammatory indicators, could be used as potential follow-up markers of the chronic radio-induced inflammation process just as its response to therapeutic treatments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Órgão Oficial da Sociedade Brasileira de Queimaduras
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IMMUNE SYSTEM
dc.subject
INFLAMMATION
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RADIATION
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CELL ADHESION MOLECULES
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
dc.title
Biomarcadores de reação inflamatória crônica em pacientes com queimaduras radiológicas (síndrome cutânea da radiação)
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-04-24T13:39:25Z
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
6-10
dc.journal.pais
Brasil
dc.journal.ciudad
Florianópolis
dc.description.fil
Fil: Portas, Mercedes. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Dubner, Diana. Laboratorio de Radiopatología en Autoridad regulatoria Nuclear; Argentina
dc.description.fil
Fil: Taja, María Emilia. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Michelin, Severino. Universidad de Buenos Aires; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.acm.org.br/viii-congresso-brasileiro-de-queimaduras-reune-em-florianopolis-os-maiores-nomes-da-especialidade/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.rbqueimaduras.com.br/summary/18
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.nroedicion
1
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
VIII Congresso Brasileiro de Queimaduras
dc.date.evento
2012-10-10
dc.description.ciudadEvento
Florianopolis
dc.description.paisEvento
Brasil
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
Sociedad Brasileña de Quemaduras
dc.source.revista
Revista Brasileira de Queimaduras
dc.date.eventoHasta
2012-10-13
dc.type
Congreso
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