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dc.contributor.author
Valdez, Alejandra Leonor
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dc.contributor.author
Torres, Mariela Analía
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dc.contributor.author
García Contreras, Rodolfo
dc.contributor.author
Nieto Peñalver, Carlos Gabriel
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dc.date.available
2024-05-22T10:48:28Z
dc.date.issued
2024-05
dc.identifier.citation
Valdez, Alejandra Leonor; Torres, Mariela Analía; García Contreras, Rodolfo; Nieto Peñalver, Carlos Gabriel; Quorum Quenchers as an Emerging New Strategy against Pseudomonas aeruginosa Infections; Multidisciplinary Digital Publishing Institute; Preprints; 5-2024; 1-17
dc.identifier.issn
2310-287X
dc.identifier.uri
http://hdl.handle.net/11336/235796
dc.description.abstract
Antimicrobial resistance (AMR) poses a critical global health threat, leading to approximately 1.27 million deaths annually from infectious diseases resistant to existing antibiotics. Factors such as antibiotic misuse and environmental contamination have accelerated AMR, with the COVID-19 pandemic exacerbating the issue due to increased antibiotic usage. However, the development of new antibiotics has stagnated, with only a few approved in recent years, and many facing resistance. Among the priority pathogens identified by the WHO, Pseudomonas aeruginosa stands out as a significant concern due to its multidrug resistance and virulence. P. aeruginosa infections are challenging to treat due to intrinsic and acquired resistance mechanisms, as well as its ability to form biofilms. Additionally, P. aeruginosa produces a plethora of virulence factors, including proteases, siderophores, and toxins, further complicating treatment. Quorum sensing (QS) systems play a crucial role in regulating bacterial physiology and virulence factor expression. P. aeruginosa employs three QS systems, making it an attractive target for quorum quenching (QQ) strategies. Enzymes such as AHL lactonases, acylases, and oxidoreductases have shown promise in inhibiting QS, thus reducing virulence without impacting bacterial growth. Furthermore, natural QS inhibitors produced by various organisms offer potential therapeutic alternatives. Despite promising results in vitro, translating QQ strategies to clinical settings remains challenging. Nevertheless, QQ represents a novel approach in combating multidrug-resistant infections and warrants further investigation as a complementary therapeutic strategy alongside traditional antibiotics. This review summarizes enzymes with Qurorum Quenching activity evaluated against the pathogen P. aeruginosa and their potential applications in combination therapies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
PSEUDOMONAS
dc.subject
QUORUM SENSING
dc.subject
ANTIBIOTICS
dc.subject
ANTIMICROBIAL
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Quorum Quenchers as an Emerging New Strategy against Pseudomonas aeruginosa Infections
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-16T14:21:04Z
dc.journal.pagination
1-17
dc.journal.pais
Suiza
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dc.journal.ciudad
Basilea
dc.description.fil
Fil: Valdez, Alejandra Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Torres, Mariela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
dc.description.fil
Fil: García Contreras, Rodolfo. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Nieto Peñalver, Carlos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
dc.journal.title
Preprints
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.preprints.org/manuscript/202405.0226/v1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.20944/preprints202405.0226.v1
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