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dc.contributor.author
Tallini, Luciana R.  
dc.contributor.author
Manfredini, Giulia  
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Rodríguez Escobar, María Lenny  
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Ríos, Segundo  
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Martínez Francés, Vanessa  
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Feresin, Gabriela Egly  
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de Souza Borges, Warley  
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Bastida, Jaume  
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Viladomat, Francesc  
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Torras Claveria, Laura  
dc.date.available
2024-05-16T11:59:47Z  
dc.date.issued
2024-04  
dc.identifier.citation
Tallini, Luciana R.; Manfredini, Giulia; Rodríguez Escobar, María Lenny; Ríos, Segundo; Martínez Francés, Vanessa; et al.; The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain; MDPI; Life; 14; 4; 4-2024; 1-15  
dc.identifier.uri
http://hdl.handle.net/11336/235489  
dc.description.abstract
Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1, while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
MDPI  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ACETYLCHOLINESTERASE  
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AMARYLLIDACEAE  
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ALKALOIDS  
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ALZHEIMER’S DISEASE  
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BUTYRYLCHOLINESTERASE  
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NARCISSUS  
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Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-05-14T13:55:45Z  
dc.identifier.eissn
2075-1729  
dc.journal.volume
14  
dc.journal.number
4  
dc.journal.pagination
1-15  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Tallini, Luciana R.. Universidad de Barcelona; España  
dc.description.fil
Fil: Manfredini, Giulia. Universidad de Barcelona; España  
dc.description.fil
Fil: Rodríguez Escobar, María Lenny. Universidad de Barcelona; España  
dc.description.fil
Fil: Ríos, Segundo. Universidad de Alicante; España  
dc.description.fil
Fil: Martínez Francés, Vanessa. Universidad de Miguel Hernández; España  
dc.description.fil
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: de Souza Borges, Warley. Universidade Federal do Espírito Santo; Brasil  
dc.description.fil
Fil: Bastida, Jaume. Universidad de Barcelona; España  
dc.description.fil
Fil: Viladomat, Francesc. Universidad de Barcelona; España  
dc.description.fil
Fil: Torras Claveria, Laura. Universidad de Barcelona; España  
dc.journal.title
Life  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2075-1729/14/4/536  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/life14040536