Artículo

Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells

Mena, Hebe AgustinaIcon ; Carestia, AgostinaIcon ; Scotti, LeopoldinaIcon ; Parborell, Maria Fernanda AgustinaIcon ; Schattner, Mirta AnaIcon ; Negrotto, SoledadIcon
Fecha de publicación: 04/02/2016
Editorial: Wiley
Revista: Journal of Thrombosis and Haemostasis
ISSN: 1538-7933
e-ISSN: 1538-7836
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Extracellular histones are highly augmented in sites of neovessel formation, such as regeneration tissues. We studied histone effect on survival and angiogenic activity of mature and progenitor endothelial cells. Extracellular histones trigger apoptosis and pyroptosis and reduce angiogenesis in vivo and in vitro. Histone blockade can be useful as a therapeutic strategy to improve angiogenesis and tissue regeneration.
Palabras clave: Antiangiogenesis , Cell Viability , Endothelial Cells , Endothelial Progenitor Cells , Histones
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/23547
URL: http://onlinelibrary.wiley.com/doi/10.1111/jth.13223/abstract
DOI: http://dx.doi.org/10.1111/jth.13223
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Mena, Hebe Agustina; Carestia, Agostina; Scotti, Leopoldina; Parborell, Maria Fernanda Agustina; Schattner, Mirta Ana; et al.; Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells; Wiley; Journal of Thrombosis and Haemostasis; 14; 2; 4-2-2016; 397-410
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