Artículo
Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
Fecha de publicación:
03/2013
Editorial:
Institute of Electrical and Electronics Engineers
Revista:
Ieee Transactions On Bio-medical Engineering
ISSN:
0018-9294
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the arti- ficial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Revert, A.; Garelli, Fabricio; Picó, J.; de Battista, Hernán; Rossetti, P.; et al.; Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 60; 8; 3-2013; 2113-2122
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