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dc.contributor.author
Motta, Lucas Federico
dc.contributor.author
Cerrudo, Carolina Susana
dc.contributor.author
Belaich, Mariano Nicolas
dc.date.available
2024-05-14T12:07:39Z
dc.date.issued
2024-01
dc.identifier.citation
Motta, Lucas Federico; Cerrudo, Carolina Susana; Belaich, Mariano Nicolas; A Comprehensive Study of MicroRNA in Baculoviruses; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 1; 1-2024; 1-18
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/235317
dc.description.abstract
Baculoviruses are viral pathogens that infect different species of Lepidoptera, Diptera, and Hymenoptera, with a global distribution. Due to their biological characteristics and the biotechnological applications derived from these entities, the Baculoviridae family is an important subject of study and manipulation in the natural sciences. With the advent of RNA interference mechanisms, the presence of baculoviral genes that do not code for proteins but instead generate transcripts similar to microRNAs (miRNAs) has been described. These miRNAs are functionally associated with the regulation of gene expression, both in viral and host sequences. This article provides a comprehensive review of miRNA biogenesis, function, and characterization in general, with a specific focus on those identified in baculoviruses. Furthermore, it delves into the specific roles of baculoviral miRNAs in regulating viral and host genes and presents structural and thermodynamic stability studies that are useful for detecting shared characteristics with predictive utility. This review aims to expand our understanding of the baculoviral miRNAome, contributing to improvements in the production of baculovirus-based biopesticides, management of resistance phenomena in pests, enhancement of recombinant protein production systems, and development of diverse and improved BacMam vectors to meet biomedical demands.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
RNA folding
dc.subject
Baculovirus
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Gene regulation
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microRNA
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Ciencias de la Información y Bioinformática
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Ciencias de la Computación e Información
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CIENCIAS NATURALES Y EXACTAS
dc.title
A Comprehensive Study of MicroRNA in Baculoviruses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-06T10:56:10Z
dc.journal.volume
25
dc.journal.number
1
dc.journal.pagination
1-18
dc.journal.pais
Suiza
dc.description.fil
Fil: Motta, Lucas Federico. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cerrudo, Carolina Susana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Belaich, Mariano Nicolas. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/1/603
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms25010603
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