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dc.contributor.author
Niu, Xueke
dc.contributor.author
Al Hatmi, Abdullah M. S.
dc.contributor.author
Vitale, Roxana Gabriela
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Lackner, Micaela
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Ahmed, Sarah A.
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Verweij, Paul
dc.contributor.author
Kang, Yingqian
dc.contributor.author
de Hoog, Sybren
dc.date.available
2024-05-10T15:55:37Z
dc.date.issued
2024-05
dc.identifier.citation
Niu, Xueke; Al Hatmi, Abdullah M. S. ; Vitale, Roxana Gabriela; Lackner, Micaela; Ahmed, Sarah A.; et al.; Evolutionary trends in antifungal resistance: a meta-analysis.; American Society for Microbiology; Microbiology Spectrum; 12; 4; 5-2024; 1-19
dc.identifier.issn
2165-0497
dc.identifier.uri
http://hdl.handle.net/11336/235153
dc.description.abstract
The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (Hypocreales, Microascales, and Mucorales) invariably showed resistance. Also the basidiomycetous orders Agaricales, Polyporales, Sporidiales, Tremellales, and Trichosporonales showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is, Onygenales, Chaetothyiales, Sordariales, and Malasseziales, in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIFUNGAL RESISTANCE
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META ANALYSIS
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Micología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Evolutionary trends in antifungal resistance: a meta-analysis.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-10T15:38:23Z
dc.journal.volume
12
dc.journal.number
4
dc.journal.pagination
1-19
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Niu, Xueke. Guizhou Medical University; China
dc.description.fil
Fil: Al Hatmi, Abdullah M. S.. University of Nizwa; Omán
dc.description.fil
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
dc.description.fil
Fil: Lackner, Micaela. Medical University of Innsbruck; Austria
dc.description.fil
Fil: Ahmed, Sarah A.. Canisius Wilhelmina Hospital; Países Bajos
dc.description.fil
Fil: Verweij, Paul. Canisius Wilhelmina Hospital; Países Bajos
dc.description.fil
Fil: Kang, Yingqian. Guizhou Medical University; China
dc.description.fil
Fil: de Hoog, Sybren. Guizhou Medical University; China
dc.journal.title
Microbiology Spectrum
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/spectrum.02127-23
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