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dc.contributor.author
Clemente, Camila Mara
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dc.contributor.author
Murillo, Javier
dc.contributor.author
Garro, Ariel Gustavo
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dc.contributor.author
Arbeláez, Natalia
dc.contributor.author
Pineda, Tatiana
dc.contributor.author
Robledo, Sara M.
dc.contributor.author
Ravetti, Soledad
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dc.date.available
2024-05-08T11:05:05Z
dc.date.issued
2024-04
dc.identifier.citation
Clemente, Camila Mara; Murillo, Javier; Garro, Ariel Gustavo; Arbeláez, Natalia; Pineda, Tatiana; et al.; Piperine, quercetin, and curcumin identified as promising natural products for topical treatment of cutaneous leishmaniasis; Springer; Parasitology Research; 123; 4; 4-2024; 1-15
dc.identifier.issn
0932-0113
dc.identifier.uri
http://hdl.handle.net/11336/234838
dc.description.abstract
Leishmania braziliensis (L. braziliensis) causes cutaneous leishmaniasis (CL) in the New World. The costs and the side effects of current treatments render imperative the development of new therapies that are affordable and easy to administer. Topical treatment would be the ideal option for the treatment of CL. This underscores the urgent need for affordable and effective treatments, with natural compounds being explored as potential solutions. The alkaloid piperine (PIP), the polyphenol curcumin (CUR), and the flavonoid quercetin (QUE), known for their diverse biological properties, are promising candidates to address these parasitic diseases. Initially, the in vitro cytotoxicity activity of the compounds was evaluated using U-937 cells, followed by the assessment of the leishmanicidal activity of these compounds against amastigotes of L. braziliensis. Subsequently, a golden hamster model with stationary-phase L. braziliensis promastigote infections was employed. Once the ulcer appeared, hamsters were treated with QUE, PIP, or CUR formulations and compared to the control group treated with meglumine antimoniate administered intralesionally. We observed that the three organic compounds showed high in vitro leishmanicidal activity with effective concentrations of less than 50 mM, with PIP having the highest activity at a concentration of 8 mM. None of the compounds showed cytotoxic activity for U937 macrophages with values between 500 and 700 mM. In vivo, topical treatment with QUE daily for 15 days produced cured in 100% of hamsters while the effectiveness of CUR and PIP was 83% and 67%, respectively. No failures were observed with QUE. Collectively, our data suggest that topical formulations mainly for QUE but also for CUR and PIP could be a promising topical treatment for CL. Not only the ease of obtaining or synthesizing the organic compounds evaluated in this work but also their commercial availability eliminates one of the most important barriers or bottlenecks in drug development, thus facilitating the roadmap for the development of a topical drug for the management of CL caused by L. braziliensis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LEISHMANIA
dc.subject
L. BRAZILIENSIS
dc.subject
ANTILEISHMANIAL DRUG
dc.subject
TOPICAL TREATMENT
dc.subject
NATURAL COMPOUND
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Piperine, quercetin, and curcumin identified as promising natural products for topical treatment of cutaneous leishmaniasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-04-29T13:33:15Z
dc.journal.volume
123
dc.journal.number
4
dc.journal.pagination
1-15
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Clemente, Camila Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Murillo, Javier. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Garro, Ariel Gustavo. Provincia de Córdoba. Ministerio de Ciencia y Técnica; Argentina
dc.description.fil
Fil: Arbeláez, Natalia. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Pineda, Tatiana. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Robledo, Sara M.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Ravetti, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
dc.journal.title
Parasitology Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s00436-024-08199-w
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00436-024-08199-w
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