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dc.contributor.author
Albertoni Borghese, Maria Florencia  
dc.contributor.author
Oronel, Lucas Humberto  
dc.contributor.author
Ortiz, Maria del Carmen  
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Majowicz, Mónica Patricia  
dc.date.available
2024-05-07T12:19:04Z  
dc.date.issued
2022-09  
dc.identifier.citation
Albertoni Borghese, Maria Florencia; Oronel, Lucas Humberto; Ortiz, Maria del Carmen; Majowicz, Mónica Patricia; Hypertension and renal disease programming: focus on the early postnatal period; Journal of the Serbian Chemical Society; Clinical Science; 136; 9-2022; 1303-1319  
dc.identifier.issn
0143-5221  
dc.identifier.uri
http://hdl.handle.net/11336/234714  
dc.description.abstract
The developmental origin of hypertension and renal disease is a concept highly supported by strong evidence coming from both human and animal studies. During development there are periods in which the organs are more vulnerable to stressors. Such periods of susceptibility are also called ´sensitive windows of exposure´. It was shown that as earlier an adverse event occurs; the greater are the consequences for health impairment. However, evidence show that the postnatal period is also quite important for hypertension and renal disease programming, especially in rodents because they complete nephrogenesis postnatally, and it is also important during preterm human birth. Considering that the developing kidney is vulnerable to early-life stressors, renal programming is a key element in the developmental programming of hypertension and renal disease. The purpose of this review is to highlight the great number of studies, most of them performed in animal models, showing the broad range of stressors involved in hypertension and renal disease programming, with a particular focus on the stressors that occur during the early postnatal period. These stressors mainly include undernutrition or specific nutritional deficits, chronic behavioral stress, exposure to environmental chemicals, and pharmacological treatments that affect some important factors involved in renal physiology. We also discuss the common molecular mechanisms that are activated by the mentioned stressors and that promote the appearance of these adult diseases, with a brief description on some reprogramming strategies, which is a relatively new and promising field to treat or to prevent these diseases.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Journal of the Serbian Chemical Society  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Programacion enfermedades  
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HIPERTENSION  
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ENFERMEDAD RENAL  
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Otras Ciencias de la Salud  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Hypertension and renal disease programming: focus on the early postnatal period  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-05-07T10:48:31Z  
dc.journal.volume
136  
dc.journal.pagination
1303-1319  
dc.journal.pais
Reino Unido  
dc.description.fil
Fil: Albertoni Borghese, Maria Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Oronel, Lucas Humberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina  
dc.description.fil
Fil: Ortiz, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina  
dc.description.fil
Fil: Majowicz, Mónica Patricia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina  
dc.journal.title
Clinical Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/clinsci/article-abstract/136/17/1303/231763/Hypertension-and-renal-disease-programming-focus?redirectedFrom=fulltext  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1042/CS20220293