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dc.contributor.author
de Charras, Yamila Lorena  
dc.contributor.author
Ramírez Rigo, María Veronica  
dc.contributor.author
Bertin, Diego Esteban  
dc.date.available
2024-05-07T09:59:25Z  
dc.date.issued
2024-03-19  
dc.identifier.citation
de Charras, Yamila Lorena; Ramírez Rigo, María Veronica; Bertin, Diego Esteban; Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber; John Wiley & Sons; The Canadian Journal Of Chemical Engineering; 19-3-2024; 1-13  
dc.identifier.issn
0008-4034  
dc.identifier.uri
http://hdl.handle.net/11336/234669  
dc.description.abstract
The testing of pharmaceutical aerosols includes measuring the aerodynamic particle size distribution, which is usually performed on cascade impactors. In the next generation  impactor (NGI), the aerosol dose is introduced through an induction port (IP), being  separated into different aerodynamic diameter ranges by seven stages and a micro-orifice collector. The IP plays an important role in estimating the oropharyngeal deposition fraction. While the IP retains mainly large particles, it also tends to retain particles in the respirable range. In this work, the deposition of particles in the IP of an NGI is studied, both experimentally and through computational fluid dynamic (CFD) simulations. Experimental tests are conducted both with the pressurized metered-dose inhaler (pMDI) alone and inconjunction with a cylindrical valved holding chamber (VHC). For each case, the total mass deposition that occurs in the VHC, IP, and NGI stages is measured, as well as the mass median aerodynamic diameter of the aerosol leaving the IP. The CFD simulations show minimal variations in results regardless of the injection method due to the relatively low velocity and spray angle of the pMDI-generated aerosol. If the flap-valve is removed from the VHC, significant particle deposition occurs upstream or within the valve region, with downstream air recirculation contributing to small particle deposition. Based on the CFD results, a correlation is proposed to accurately predict the particle escape fraction of the IP and VHC, which allows estimation of the tannin distribution of particles collected in theNGI stages, especially those corresponding to the range of respirable particles.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
John Wiley & Sons  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CASCADE IMPACTOR  
dc.subject
CFD  
dc.subject
INHALATION  
dc.subject
METERED-DOSE INHALER  
dc.subject.classification
Ingeniería Química  
dc.subject.classification
Ingeniería Química  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-04-23T13:32:59Z  
dc.identifier.eissn
1939-019X  
dc.journal.pagination
1-13  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: de Charras, Yamila Lorena. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina  
dc.description.fil
Fil: Ramírez Rigo, María Veronica. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina  
dc.description.fil
Fil: Bertin, Diego Esteban. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina  
dc.journal.title
The Canadian Journal Of Chemical Engineering  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cjce.25250  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cjce.25250