Artículo

Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells

Fernández, Marisa MarielIcon ; Ferragut, Fátima; Cardenas Delgado, Victor ManuelIcon ; Bracalente, María CandelariaIcon ; Bravo, Alicia Ines; Cagnoni, AlejandroIcon ; Nuñez, Myriam Carmen; Morosi, Luciano GastónIcon ; Quintá, Héctor RamiroIcon ; Espelt, Maria VictoriaIcon ; Troncoso, María FernandaIcon ; Wolfenstein, Carlota ElisaIcon ; Mariño, Karina ValeriaIcon ; Malchiodi, Emilio LuisIcon ; Rabinovich, Gabriel AdriánIcon ; Elola, Maria TeresaIcon
Fecha de publicación: 26/04/2016
Editorial: Elsevier Science
Revista: Biochimica et Biophysica Acta- General Subjects
ISSN: 0304-4165
e-ISSN: 1878-2434
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells. ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell-cell interactions. Gal-8 is a "tandem-repeat"-type galectin, known as a matricellular protein involved in cell adhesion. Here, we analyzed the physical interaction between both molecules in breast cancer cells and the functional relevance of this phenomenon.
Palabras clave: Galectin-8 , Breast Cancer Cell , Alcam/Cd166 , Receptor Segregation
 
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Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/23462
URL: http://www.sciencedirect.com/science/article/pii/S0304416516301246
DOI: http://dx.doi.org/10.1016/j.bbagen.2016.04.019.
URL: http://dx.doi.org/ 27130882
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Fernández, Marisa Mariel; Ferragut, Fátima; Cardenas Delgado, Victor Manuel; Bracalente, María Candelaria; Bravo, Alicia Ines; et al.; Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells; Elsevier Science; Biochimica et Biophysica Acta- General Subjects; 1860; 10; 26-4-2016; 2255-2268
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